“Su Wen-Yin Yang Category Theory” says that in Chinese medicine, “liver is more delicate than other four internal organs”, “liver being yin substantial and being yang functionally ” and “liver being shaoyang in yin”, which reflected that in human body, yin and yang are mutual rooted and can be conversed. Liver fibrosis is an inevitable stage during the development of chronic liver disease to cirrhosis. The research of liver fibrosis reversal in early stage is of great significance in clinic medicine. To discuss the pathogenesis and therapy from the perspective of yin and yang can provide a fresh idea in clinical treatment.