To study the mechanism of Chuyou Yuyang Granules in preventing ulcer relapse.Methods:A total of 100 patients with peptic ulcer were randomly divided into western medicine group and integrated Chinese and western medicine group; the western medicine group was given omeprazole, amoxicillin and imidazole, while the other group were also given Chuyou Yuyang Granules on the basis of western medicine groups treatment. Both groups were treated for six weeks. Changes in serum VEGF, PGE2 and bFGF levels before and after the treatment of six weeks and a year were detected by ELISA methods.Results:After the treatment, significant differences in serum VEGF, PGE2 and bFGF levels were observed in both groups comparing with the levels before the treatment (P<0.05). Morever, after a year, changes were significantly different between the two groups (P<0.05).Conclusion:Chuyou Yuyang Granules may promote the expression of VEGF, bFGF and PGE2, which effectively improve the ulcer healing process.