To observe the clinical effect of tuina combined with Huoxue Huayu decoction in the treatment of soft tissue swelling due to bone trauma, and thus to find an effective method to address this problem. Methods: A total of 92 cases of patients who enrolled into our hospital from August 2013 to June 2015 were randomly divided into two groups, forty-six in each. The observation group were treated with tuina combined with Huoxue Huayu decoction and the control group with Huoxue Huayu decoction solely. Huoxue Huayu decoction was taken orally, with 1 dose a day(could be taken by one time or two times), lasting two weeks. Tuina, 1 time a day, 20 min for a time, lasting for one months. After treatment, the clinical effects of the two groups were compared, including the improvement of limb swelling, duration to total swelling elimination, relief of pain, and total effective rate. Results: After treating for two weeks and four weeks, the pain relief and swelling degree in the two groups were significantly improved than before(P<0.05). After 4 weeks treatment, the swelling degree and pain relief of the patients in the observation group were significantly different from those of the control group (P<0.05). The swelling completely eliminated in the observation group at (34.3±4.6) d, and it was (41.5±5.7) d in the control group. The difference was statistically significant (P<0.05). After treatment, the total effective rate was 94.5% in the observation group and 73.4% in the control group, and there were statistical difference between the two groups.(P<0.05). Conclusion: Huoxue Huayu Decoction combined with tuina has a satisfying performance as it could relieve soft tissue swelling due to bone trauma in a shorter time and relieve the pain effectively.