| 引用本文:孙榕，回世洋.化瘀明目汤治疗不同时期糖尿病视网膜病变疗效对比观察及其对VEGF的影响[J].世界中医药,2016,(01):. |
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| 化瘀明目汤治疗不同时期糖尿病视网膜病变疗效对比观察及其对VEGF的影响 |
| In Different Periods of Diabetic Retinopathy in the Observation of the Curative Effect of Treatment of HuaYuMingMu Decoction and Its Influence on VEGF |
| 投稿时间：2015-06-19 |
| DOI：10.3969/j.issn.1673-7202.2016.01.018 |
| 中文关键词: 化瘀明目汤 糖尿病视网膜病变 VEGF |
| English Keywords:HuaYuMingMu Decoction Diabetic Retinopathy VEGF |
| 基金项目:辽宁省科学技术奖获奖项目（编号：2001J 3 159） |
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| 中文摘要: |
| 目的：观察对比化瘀明目汤对不同时期糖尿病视网膜病变的疗效，同时检测其对血管内皮生长因子（Vascular Endothelial Growth Factor,VEGF）表达的影响。方法：随机选取2011年1月至2015年2月，于我院眼科门诊部和住院部就诊的120例患者，本研究分为4个组，符合增殖期糖尿病视网膜病变（Proliferation Stage of Diabetic Retinopathy，PDR）诊断标准患者60例，以就诊先后顺序编号，单盲随机数字表法分为增殖期组和对照1组，每组各30例；符合非增殖期糖尿病视网膜病变（Non proliferative Diabetic Retinopathy，NPDR）诊断标准患者60例，以上述方法单盲随机分为非增殖期组和对照2组，每组各30例。治疗前后，根据国际标准视力表检查患者视力；治疗前后抽取患者外周血3 mL，检查患者全血黏度（mPa·s）和胆固醇（mmol/L）的等血液流变学变化。用酶联免疫吸附法（ELISA）试剂盒定量检测VEGF的表达情况。结果：治疗前各组间视力、全血黏度、胆固醇、VEGF比较差异均无统计学意义（P>0.05），治疗后增殖期组、对照1组视力优于各自的治疗前（P<0.05），而全血黏度、胆固醇、VEGF比较均低于各自的治疗前（P<0.05）。治疗后非增殖期组视力优于对照2组和增殖期组（P<0.05），而全血黏度、胆固醇、VEGF低于对照2组和增殖期组（P<0.05）。增殖期组总有效率为53.33%，对照1组总有效率为50.00%，非增殖期组总有效率为83.33%，对照2组总有效率为56.66%。经χ2检验，非增殖期组优于对照2组和增殖期组（P<0.05），增殖期组和对照1组差异无统计学意义（P>0.05）。结论：化瘀明目汤在治疗DR非增殖期疗效显著，有助于提高非增殖期糖尿病视网膜病变患者视力，改善血液循环等作用，同时下调了VEGF的表达。化瘀明目汤对增殖期糖尿病视网膜病变患者疗效不显著。 |
| English Summary: |
| To observe the effect of the contrast HuaYuMingMu Decoction on the curative effect of diabetic retinopathy in different periods.At the same time，the detection effect of the expression of VEGF.Methods:Randomly selected in January 2011 2015 years 2 months，in ophthalmology outpatient department and inpatient department treatment of 120 patients，this study divided into four groups，meet the diagnostic criteria of 60 patients for proliferative diabetic retinopathy(PDR)，to the visiting sequence number，single blind randomized digital table method is divided into proliferative group and the control group，each with 30 cases in each; in line with the non proliferative diabetic retinopathy(NPDR)diagnostic criteria were 60 cases，with the method of single blind randomized into non proliferative group 2 and control group，each with 30 cases in each.Before and after treatment，according to the international standard acuity visual acuity; before and after treatment were collected peripheral blood 3ml，examination of whole blood viscosity(mpa.s)and cholesterol(mmol / L).The expression of VEGF is detecting of by using enzyme linked immunosorbent assay(ELISA)kit.Results:The treatment among the three groups before eyesight，blood viscosity，cholesterol，VEGF showed no significant difference(P>0.05)，after treatment of proliferative group，control group 1 vision is better than the respective treatment before(P<0.05)，and viscosity of whole blood，cholesterol and vascular endothelial growth factor(VEGF)comparison were lower than the respective treatment before(P<0.05).After the treatment of non proliferative Vision Group is better than control group 2 and proliferation group(P<0.05)，and viscosity of whole blood，cholesterol and vascular endothelial growth factor(VEGF)below the control group 2 and proliferation group(P<0.05).Proliferative phase group，the total effective rate was 53.33% control 1 group，the total effective rate was 50.00%，non proliferative group total efficiency was 83.33%，the control 2 group，the total efficiency was 56.66%.By x2 test，non proliferative group is better than that of the control group 2 and proliferation group(P<0.05)and proliferative group and control group，a difference was not statistically significant(P>0.05).Conclusion:HuaYuMingMu Decoction in the treatment of DR in non proliferative phase has a significant effect，help to improve the non proliferative diabetic retinopathy patients visual acuity，improve blood circulation effect，and down regulated the expression of VEGF.HuaYuMingMu Decoction is not significant on proliferative diabetic retinopathy patients. |
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