To analyze general medication rules in treating spleenstomach disharmony in Dictionary of Traditional Chinese Medicine Prescriptions. Methods: To collect and filter the prescriptions in Dictionary of Traditional Chinese Medicine Prescriptions, and categorize and standardize the name of Chinese herb.Then input these prescriptions into the traditional Chinese medicine inheritance platform(V2.5) and analyze the general medication rule in treating spleenstomach disharmony by unsupervised data mining methods include improved mutual information method and complex system entropy clustering and unsupervised entropy clustering hierarchy. Results: There were 186 formulas selected and 175 kinds of Chinese herbs were involved. There were 40 kinds of herbs used more than 10 times. Most of them are warmnatured, taste pungent, and attributed to spleen meridian. The numbers of support degree setting is 37（20%), which got 21 herb pairs and combination. Also, thirtyfour core combinations which can be used in new prescriptions and 17 potential prescriptions were achieved. A total of 124 prescriptions contain liquorice(Gancao) were screened out, invo1ving 127 herbs. Besides, 18 herb pairs and core combination were achieved by setting the number of support to 74（60%). Conclusion: The most frequent used drugs in regulating spleenstomach disharmony are qitonifying drugs, qiregulating drugs, interiorwarming drugs, dampdissolving drugs, and most of which are warmnatured, pungent and be attributive to spleen meridian. YiGongSan could be used as the basic formula to treat spleenstomach disharmony. The core treatment method are replenishing qi and invigorating the spleen, regulating qi and harmonizing stomach, drying dampness and resolving phlegm, and warming spleen and dispelling cold.