| 引用本文:龙天雷，黄腾蛟，高巧玲，许娜，杨晶，王朝辉.通经利浊针法对急性痛风性关节炎大鼠模型影响的实验研究[J].世界中医药,2016,(02):. |
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| 通经利浊针法对急性痛风性关节炎大鼠模型影响的实验研究 |
| Effect of “Dredging Channels and Eliminating Turbid” Acupuncture on the Level of TNF-α in Mice with Acute Gouty Arthritis——an Experimental Study |
| 投稿时间：2016-01-12 |
| DOI：10.3969/j.issn.1673-7202.2016.02.008 |
| 中文关键词: 通经利浊针法 痛风性关节炎 肿瘤坏死因子 实验研究 |
| English Keywords:“Dredging Channels and Eliminating Turbid” acupuncture Acute gouty arthritis Tumor necrosis factor α Experimental study |
| 基金项目:国家重点基础研究发展计划(“973”计划)资助项目（编号：2014CB543100）；吉林省教育科学“十二五”规划课题（编号：GH13240）；吉林省科技发展计划项目（编号：2016921） |
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| 中文摘要: |
| 目的：比较通经利浊针法与秋水仙碱对急性痛风性关节的治疗效果。方法：将40只雄性实验昆明种大鼠随机分成空白组（不造模）、模型组（造模但不治疗）、西药组（秋水仙碱灌胃）和针刺组。造模采用微晶型尿酸钠混悬液注射大鼠后肢膝关节腔的方法。检测血清中肿瘤坏死因子（TNF-α）的含量。结果：针刺组、西药组与模型组组间比较均有统计学意义（P<0.05），针刺组与西药组比较有统计学意义（P<0.05）。结论：通经利浊针法可降低昆明种大鼠急性痛风性关节炎模型血清中TNF-α的含量。 |
| English Summary: |
| To compare the curative effect of “Dredging Channels and Eliminating Turbid” acupuncture and colchicine on acute gouty arthritis.Methods:Forty male rats were randomly divided into blank group (without modeling), model group (modeling without treatment), western medicine group (given colchicine orally) and acupuncture group.The rat models were made by injecting micro-crystal-sodium-urate suspension on knee joint cavity of hind limbs.Then to detect the content of tumor necrosis factor α(TNF-α)in serum.Results: 1) The TNF-α level disparity among blank group and model group are significant(P<0.05), which indicates the success of modeling.2) TNF-α levels in the western medicine group differs significantly from that of the blank group(P<0.05), indicating the curative effect of colchicine.3) TNF-α levels of the acupuncture group has significant difference with that of the western medicine group(P<0.05), as a sign that the performance of acupuncture superior to that of colchicine.Conclusion: “Dredging Channels and Eliminating Turbid” acupuncture can decrease the level of TNF-α in rats with acute gouty arthritis. |
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