In Chinese history and culture, it is believed that human beings are originated from mother nature and the primordial qi is the common material basis of both human beings and the nature. This article described yin and yang formed by primordial qi whose changes are regarded as the origin of all beings; the correlation between movements and changes of yin-yang represents the relationship between the five elements. The same origin of all things in the universe is the theoretical basis of the correlations of four seasons-yin yang-five zang organs. This essay expressed the idea under the perspective of four seasons that it is an important aspect to regard five zang organs’ physical function as reflection of the “correspondence between nature and human” concept. Four seasons-yin yang-five zang organs in Huangdi’s Internal Classic is an important thinking mode in exploring the law of life in Chinese medicine.