To observe the clinical effect of Yangfei fomula’s effect on reducing postoperative complications for elderly patients with advanced non-small cell lung cancer (NSCLC) after Argon-Helium cryoablation. Methods:A total of 86 elderly advanced NSCLC patients were included in this study. Patients were divided into 2 groups. The group of combination of traditional Chinese and western medicine (group I) including 45 patients was given the treatment of Yangfei fomula combined with best supportive care (BSC) after argon-helium cryoablation. The group of western medicine multi-modality (group II) including 41 patients was given the treatment of BSC. Postoperative complications, PS score and clinical symptoms were observed. Results:1)Postoperative complications: The most common complications were aggravating cough, pain of surgical site, hemoptysis and blood in phlegm. The relief time of cough in group I (5.11±2.17 d) was shorter than group II (6.68±3.12d) with statistical difference(P<0.05). The relief time of pain in group I (3.47±1.92d) was shorter than group II (5.35±2.06d) with statistical difference(P<0.05). 2) PS score: The PS score of group I was superior to group II 1 month and 3 month after surgery respectively (P<0.05). There was no statistical difference 1 week after surgery (P>0.05). 3) Clinical symptoms: The improvement of expectoration, god fatigue, and loss of appetite in group I was superior to group II 1 month after surgery(P<0.05). The improvement of cough, expectoration, god fatigue, dry throat, and loss of appetite in group I was superior to group II 3 month after surgery(P<0.05). Conclusion:Yangfei fomula could reduce postoperative complications and improve physical condition of elderly patients with advanced non-small cell lung cancer (NSCLC) after Argon-Helium cryoablation.