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引用本文:吴鋆1，李葆青1，汪用文1，王爱强1，王瑾1，沙金玲1，吴松青1，于浩生2.补脾益肾清热法治疗原发性干燥综合征的临床疗效观察[J].世界中医药,2016,(02):.

补脾益肾清热法治疗原发性干燥综合征的临床疗效观察

Clinical Observation on Efficacy of the Therapy of Clearing Heat by Tonifying Spleen and Invigorating Kidney on Treating Primary Sjogren’s Syndrome

投稿时间：2015-04-23

DOI：10.3969/j.issn.1673-7202.2016.02.015

中文关键词: 补脾益肾清热法原发性干燥综合征疗效

English Keywords:Principle of Clearing Heat Tonifying Spleen and Invigorating Kidney Primary Sjogren’s Syndrome Efficacy

基金项目:

作者	单位
吴鋆1，李葆青1，汪用文1，王爱强1，王瑾1，沙金玲1，吴松青1，于浩生2	1 中国中医科学院望京医院，北京，100102； 2 山东省诸城市人民医院，潍坊，262200

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中文摘要:

目的：评价补脾益肾清热法治疗原发性干燥综合征（Primary Sjogren’s Syndrome，PSS）的临床疗效及安全性。方法：纳入PSS患者45例，予补脾益肾清热法治疗，疗程12周，于0周、12周观察中医证候积分、口干（VAS）评分、眼干（VAS）评分、ESR、CRP、RF、IgG、IgA、IgM，安全性指标，并记录不良事件等，评价中医证候疗效。结果：与治疗前比较，治疗12周后患者中医证候积分、口干（VAS）评分、眼干（VAS）评分、ESR、CRP、IgG显著降低，差异有统计学意义（P<0.01），RF、IgA、IgM差异无统计学意义（P>0.05），45例患者中，中医证候疗效显效19例，有效18例，无效8例，总有效率82.2%。结论：补脾益肾清热法能显著改善PSS患者的口干、眼干、中医证候积分及炎症指标，是治疗PSS安全有效的药物。

English Summary:

To evaluate the efficacy and safety of the therapy of clearing heat by tonifying spleen and invigorating kidney on treating primary Sjogren’s Syndrome(PSS). Methods: A total of 45 patients with PSS participated in the study and received treatment based on the therapy of clearing heat by tonifying spleen and invigorating kidney for 12 weeks. TCM syndrome integrals, dry mouse(VAS), dry eyes(VAS), ESR, CRP, RF, IgG, IgA, IgM and the safety indexes were evaluated in first week and 12th week. The side effects were recorded and the effectiveness evaluated. Results: At 12th weeks, the TCM syndrome integrals, dry mouth(VAS), dry eyes(VAS), ESR, CRP, IgG were significantly reduced with statistical difference （P<0.01）. There was no statistical difference in RF, IgA, IgM（P>0.05）. In the 45 patients, there were 19 patients showed significant effectiveness, 18 patients had effectiveness and 8 patients showed no effectiveness. The total effective rate was 82.2%. Conclusion: Clearing heat by tonifying spleen and invigorating kidney has efficacy on treating PSS. The therapy could improve the condition of PSS patients with dry mouth, dry eyes, TCM syndrome integrals and inflammation index.

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