| 引用本文:贾慧1，王刚2，〖FK(〗任磊〖FK)〗1，杨博华2.不同中医辨证分型糖尿病溃疡与踝肱比值及激光多普勒灌注量的相关性[J].世界中医药,2016,(02):. |
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| 不同中医辨证分型糖尿病溃疡与踝肱比值及激光多普勒灌注量的相关性 |
| The Correlation between Ankle Brachial Ratio and Laser Doppler Blood Flow Perfusion among Different Syndromes of Diabetes Ulcer |
| 投稿时间：2015-08-24 |
| DOI：10.3969/j.issn.1673-7202.2016.02.017 |
| 中文关键词: 糖尿病溃疡 踝肱比值 激光多普勒灌注量 中医辨证分型 |
| English Keywords:Diabetes ulcer Ankle brachial ratio Laser Doppler perfusion percentage Traditional Chinese Medicine |
| 基金项目:北京市中医药科技项目(编号:WZF2012—04)——“溃疡油外敷治疗糖尿病足溃疡的临床规范化研究” |
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| 中文摘要: |
| 目的:通过研究糖尿病溃疡患者踝肱比值及激光多普勒血流灌注量,来探讨两者与不同的中医辨证分型的关系。方法:通过临床辨证分型将糖尿病溃疡分为气虚血瘀型和湿热蕴结型,并设立正常对照组,检测血沉、胆固醇、血脂、低密度脂蛋白、高密度脂蛋白、踝肱比值、激光多普勒血流灌注量在不同组别中的变化。结果:糖尿病溃疡患者踝肱比值较正常对照组明显降低,且气虚血瘀组<湿热蕴结组,组间差异有统计学意义(P<0.01);激光多普勒血流灌注百分比较正常对照组明显降低,且气虚血瘀组<湿热蕴结组,组间差异有统计学意义(P<0.01);经Logistic回归分析得出糖尿病溃疡中医辨证分型与糖尿病病程、踝肱比值密切相关。结论:踝肱比值及激光多普勒血流灌注量与糖尿病溃疡患者的不同中医辨证分型具有一定相关性,对于不同的证型差异有统计学意义,说明糖尿病溃疡患者均存在不同程度的缺血,气虚血瘀型缺血程度更加明显,糖尿病病程及踝肱比值与糖尿病溃疡的中医辨证分型的相关性最大。 |
| English Summary: |
| To explore the correlation between ankle brachial ratio and laser Doppler blood flow perfusion among different syndrome types of diabetes ulcer patients. Methods: To divide diabetes ulcer into qi deficiency and blood stasis type and dampness and hot accumulation type based on clinical TCM(traditional Chinese medicine) differentiation, and set up a normal control group. To detect the erythrocyte sedimentation rate, cholesterol, blood lipid, low density lipoprotein(LDL)-cholesterol, high-density lipoprotein(HDL)-cholesterol, ankle brachial volume ratio, laser Doppler perfusion changes in different groups. Results: Diabetic ulcers ankle brachial ratio is significantly lower than that of the normal control group, besides, the ratio of dampness and hot accumulation group is lower than that of the qi deficiency and blood stasis group(P<0.01). Compared to normal control group, laser Doppler perfusion percentage significantly decreased. In addition, qi deficiency and blood stasis group decreased greater than that of the damp and hot accumulation group(P<0.01). Logistic regression analysis shows that TCM syndrome types of diabetes ulcer have close correlation with ankle brachial ratio and laser Doppler blood flow perfusion. Conclusion: There exists certain correlation between ankle brachial ration and laser Doppler perfusion. The differences among groups illustrate diabetes ulcer patients suffer from varying extent of blood deficiency, and this is more obvious in qi deficiency and blood stasis type patients. Also, TCM syndrome types of diabetes ulcer have strong relevance with ankle brachial ratio and the duration of diabetes. |
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