| 引用本文:张会平，刘宇，高睿，赵月.桑椹首乌补脑颗粒对老年性痴呆模型大鼠血清SOD、MDA含量及脑组织β淀粉样蛋白表达的影响[J].世界中医药,2016,(02):. |
|
| 桑椹首乌补脑颗粒对老年性痴呆模型大鼠血清SOD、MDA含量及脑组织β淀粉样蛋白表达的影响 |
| Effects of Sangshen Shouwu Bunao Granule on the Level of SOD, MDA and the Expression of β-amyloid in Dementia Model Rats Serum |
| 投稿时间：2015-01-13 |
| DOI：10.3969/j.issn.1673-7202.2016.02.029 |
| 中文关键词: 老年性痴呆 桑椹首乌补脑颗粒 学习记忆 血管活性物质 β淀粉样蛋白 |
| English Keywords:Alzheimer’s disease Sangshen Shouwu Bunao granule Learning and memory capability Vasoactive substances β-amyloid |
| 基金项目:济南市2007年科学技术发展计划第五批项目（编号：200705089-1） |
|
| 摘要点击次数: 1012 |
| 全文下载次数: 1129 |
| 中文摘要: |
| 目的：研究桑椹首乌补脑颗粒防治老年性痴呆的作用机制，为指导临床用药提供实验依据。方法：观察服用桑椹首乌补脑颗粒后，老年性痴呆模型Wistar大鼠学习记忆功能、血管活性物质（SOD、MDA）及脑组织β淀粉样蛋白含量的变化。结果：桑椹首乌补脑颗粒能够促进学习记忆功能的恢复，升高SOD、降低MDA含量，降低海马区β淀粉样蛋白的表达。结论：桑椹首乌补脑颗粒防治老年性痴呆可能是通过下调脑组织β淀粉样蛋白的表达，升高SOD水平、降低MDA含量，减少脑组织损伤有关。 |
| English Summary: |
| To explore the mechanism of Sangshen Shouwu Bunao granule on preventing dementia and provide data support on clinical treatment. Methods:To detect the changes of SOD, MDA and β-amyloid on Alzheimer Wistar rats after giving Sangshen Shouwu Bunao granule. Results:Sangshen Shouwu Bunao granule can promote the learning and memory capabilities of rats, increase SOD, decrease MDA level and down regulate amyloid β expression. Conclusion:Sangshen Shouwu Bunao granule can prevent Alzheimer’s disease. This is possibly because it can reduce β-amyloid in brain tissue, increase levels of SOD, and decrease MDA levels; thus to repair brain tissue damage. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
