| 引用本文:陈诚，李明，周耀庭，刘仁慧，师一民.小儿喘宝对哮喘大鼠血清及肺泡灌洗液Th1/Th2平衡的影响[J].世界中医药,2016,(02):. |
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| 小儿喘宝对哮喘大鼠血清及肺泡灌洗液Th1/Th2平衡的影响 |
| The Effect of Xiao’er Chuanbao Decoction on the Balance of Th1/Th2 in Serum and Bronchoalveo Larlavage Fluid of Asthma Rats |
| 投稿时间：2015-09-15 |
| DOI：10.3969/j.issn.1673-7202.2016.02.032 |
| 中文关键词: 小儿喘宝 哮喘 Th1/Th2 |
| English Keywords:Xiao’er Chuanbao decoction Asthma Th1/Th2 |
| 基金项目:北京市教育委员会2014年首都中医药研究专项(编号:14ZY03);北京中医药“薪火传承3+3工程”周耀庭名老中医工作室项目;周耀庭全国名老中医药专家传承工作室建设项目 |
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| 中文摘要: |
| 目的:研究小儿喘宝对哮喘大鼠血清及肺泡灌洗液中Th1/Th2平衡的影响,探索其治疗哮喘的作用机制。方法:采用卵蛋白(OVA)致敏、激发的方式制作大鼠慢性哮喘模型,以地塞米松为对照药。通过对哮喘大鼠支气管肺泡灌洗液(BALF)细胞涂片中嗜酸性粒细胞(EOS)的计数,血清及肺泡灌洗液(BALF)中IFN-γ、IL-4含量以及IFN-γ/IL-4比值的测定,探索小儿喘宝治疗哮喘大鼠的作用机制。结果:小儿喘宝可减轻大鼠的哮喘症状,减少BALF中EOS的数量,降低血清及BALF中IL-4的含量,升高血清及BALF中IFN-γ的含量,升高IFN-γ/IL-4的比值。结论:小儿喘宝能升高哮喘大鼠血清及肺泡灌洗液中IFN-γ/IL-4的比值,从而纠正失衡的Th1/Th2,这可能是小儿喘宝调节哮喘的作用机制之一。 |
| English Summary: |
| To investigate the effects of Xiao’er Chuanbao decoction on Th1/Th2 balance in asthma rats and its mechanism. Methods: To make the chronic asthma models by Ovalbumin(OVA) sensitizing and stimulating. Dexamethasone was used as the control drug. To explore the mechanism of Xiao’er Chuanbao decoction in treating asthmatic rats by counting the number of eosinophils (EOS) in bronchoalveo larlavage fluid (BALF), determining the contents of IFN-γ, IL-4 in serum and BALF, and calculating the ratio of IFN-γ and IL-4. Results: Xiao’er Chuanbao decoction can relieve asthma symptoms reduce the number of EOS in BALF, raise the level of IL-4 in serum and BALF deduce the level of IFN-γ and increase IFN-γ/ IL-4 ratio. Conclusion: Xiao’er chuanbao decoction can rise the ratio of IFN-γ/ IL-4, and thus balancing Th1/Th2. This might be its mechanism in treating asthma. |
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