世界中医药

目的：比较红花注射液和注射用红花黄色素药理作用的区别，为临床用药提供参考。方法：选择体重相近的小白鼠，给予相同剂量的红花注射液和注射用红花黄色素，观察小白鼠单核-巨噬细胞碳粒廓清指数K和吞噬指数α，变化，比较2组药品对小白鼠免疫能力的影响；观察小白鼠舒张压和收缩压的变化值，比较2组药品对小白鼠血压的影响；观察小白鼠的入睡例数、入睡比例以及入睡时间，比较2组药品对小白鼠中枢镇静作用的影响。结果：红花注射液组显著升高小白鼠的单核-巨噬细胞碳粒廓清指数K和吞噬指数α，较对照组小白鼠具有统计学意义（P<0.05）但注射用红花黄色素组的免疫效果不明显；红花注射液组和注射用红花黄色素组均显著降低小白鼠的收缩压和舒张压，均较对照组具有统计学意义（P<0.05），但注射用红花黄色素组降压效果更加明显；红花注射液注射液显著促进小白鼠睡眠，入睡比例和入睡时间均较对照组小白鼠具有统计学意义（P<0.05），但注射用红花黄色素组镇静效果不明显。结论：红花注射液组具有较好的免疫作用、较强的降血压作用、较强的中枢镇静作用，但注射用红花黄色素仅有较强的降血压作用，降压效果更加明显。

English Summary:

To compare the difference analysis of pharmacological effects of shuxuening injection and ginkgo diterpene lactone meglumine injection，for suitable clinical as reference.Methods:Choose the similar traits inmice，treated with different doses of shuxuening injection and ginkgoterpene lactones and two meglumine injection comparison of mousemononuclear macrophage carbon particle clearance index K and index of phagocytosis of alpha，comparison of two groups of processed products onthe immunity of mice; comparison of mouse diastolic and systolic blood pressure changes in value，effect comparison two groups of processed products on blood pressure in mice; comparison of the number of cases，mice sleep sleep time ratio and the influence，compared two groups of processed products on central sedative effects in mice.Results:The high dose of Shuxuening injection group and ginkgo diterpene lactone meglumine injection group were significantly increased in mice monocyte-macrophage carbon particle clearance index K and index of phagocytosis of alpha，were lower than those in the control group of mice with significant difference(P<0.05)，but the immune effects of ginkgo diterpene lactone meglumine injection group more obvious; high dose of shuxuening injection group and ginkgo diterpene lactone meglumine injection group were significantly decreased in mice systolic and diastolic blood pressure were lower than those in the control group，with significant difference(P<0.05)，but ginkgo diterpene lactone meglumine injection group hypotensive effect is more obvious; high dose of shuxuening injection group and ginkgo diterpene lactone meglumine injection group was significantly accelerated mice sleep，sleep time ratio were lower than those in the control group of mice with significant difference(P<0.05)，but t ginkgo diterpene lactone meglumine injection group was more significant sedative effect.Conclusion:Shuxuening injection and ginkgo diterpene lactone meglumine injection were two meglumine with immune function，good strong，the blood pressure lowering effect of strongcentral sedation，but ginkgo diterpene lactone meglumine injection strong pharmacological activity.

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