| 引用本文:周琦，张大炜，刘红旭，张竹华，李爱勇，林晓烁，田伟，李腾飞，邢文龙.丹参类静脉制剂对择期PCI围手术期心肌损伤的保护作用研究[J].世界中医药,2016,(03):. |
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| 丹参类静脉制剂对择期PCI围手术期心肌损伤的保护作用研究 |
| Observation of Salvia Miltiorrhiza Intravenous Agents on Selective PCI Perioperative Myocardial Injury |
| 投稿时间：2016-02-24 |
| DOI：10.3969/j.issn.1673-7202.2016.03.003 |
| 中文关键词: 丹参 静脉制剂 PCI围手术期心肌损伤 |
| English Keywords:Salvia miltiorrhiza Intravenous agents PCI perioperative myocardial injury |
| 基金项目:国家自然科学基金项目（编号：81273741）;国家中医药管理局重点学科基金;北京市215人才基金;北京市十百千人才基金 |
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| 中文摘要: |
| 目的：观察丹参类静脉制剂对择期PCI围手术期心肌损伤的保护作用。方法：非同期对照观察常规治疗及加用丹参粉针、丹参酮ⅡA注射液、丹红注射液，对择期PCI的不稳定心绞痛（Unstable Angina，UA）患者血清心肌标志物肌酸激酶同工酶（Myocardial-bound Creatine Kinase，CK-MB）的影响，探讨丹参类制剂对择期PCI围手术期的心肌保护作用。结果:PCI术后与术前相比较，常规组术后血清中CK-MB水平升高，差异有统计学意义（P<0.05）；丹粉组术后血清中CK-MB水平较术前亦有升高，差异无统计学意义（P>0.05）；丹酮组术后血清中CK-MB水平较术前有所降低，其差异接近统计学意义（P=0.053）；丹红组术后血清中CK-MB水平较术前有所降低，差异有统计学意义（P=0.033）。结论：丹参类静脉制剂对择期PCI围手术期心肌损伤的具有一定的保护作用，以丹红注射液作用最为明确。 |
| English Summary: |
| To observe the effect of salvia miltiorrhiza intravenous preparations on selective PCI perioperative myocardial injury. Methods: To observe the effect of routine treatment combined with salvia miltiorrhiza powder injection, tanshinoneⅡA injection, Danhong injection respectively on serum myocardial markers Myocardial-bound Creatine Kinase(CK-MB) in the serum of patients with unstable Angina(UA) after selective PCI. Then discuss its protective mechanism on perioperative myocardium. Results: Compared with before treatment, the CK-MB level in the routine treatment group had increased with statistically difference(P<0.05). CK-MB level in the salvia miltiorrhiza group also increased with no statistical difference(P>0.05). CK-MB level in Tanshinone group decreased(P=0.053), and that of Danhong group also decreased(P=0.033). Conclusion: Salvia miltiorrhiza intravenous preparation, especially Danhong injection, has certain effect on PCI perioperative myocardial injury. |
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