| 引用本文:安宏，赵丹丹，于娜，穆倩倩，张毅，方心，左加成，高雅，赵保胜，高思华.降糖消渴颗粒联合二甲双胍对2型糖尿病小鼠糖脂代谢的影响[J].世界中医药,2016,(03):. |
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| 降糖消渴颗粒联合二甲双胍对2型糖尿病小鼠糖脂代谢的影响 |
| Effect of Jiangtang Xiaoke Granule Combined with Metformin on Glucose and Lipid Metabolism in Type 2 Diabetic Mice |
| 投稿时间：2015-05-16 |
| DOI：10.3969/j.issn.1673-7202.2016.03.031 |
| 中文关键词: 降糖消渴颗粒 二甲双胍 联合用药 2型糖尿病 |
| English Keywords:Jiangtang Xiaoke granule Metformin Combined medication Type 2 diabetes |
| 基金项目:国家科技重大专项子课题（编号:2012ZX09103201-005） |
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| 中文摘要: |
| 目的：探讨降糖消渴颗粒联合二甲双胍对2型糖尿病小鼠糖脂代谢的影响。方法：ICR小鼠高脂饲料喂养4周，腹腔注射链脲佐菌素（STZ）100 mg/kg，建立2型糖尿病小鼠模型。设正常对照组、模型组、西药组（二甲双胍）、中西药联合3组（降糖消渴颗粒低、中、高剂量分别与二甲双胍同用）。给药4周后，检测小鼠的体重、空腹血糖(Fasting Blood-glucose，FBG)、血清胰岛素（Insulin，Ins）、胰高血糖素、糖耐量（Oral Glucose Tolerance Test，OGTT）、血脂，并计算胰岛素敏感指数（Insulin Sensitivity Index，ISI）。结果：降糖消渴颗粒联合二甲双胍可降低糖尿病小鼠的体重（P<0.05）、空腹血糖（P<0.01）、血清胰岛素水平（P<0.05）、胰高血糖素水平（P<0.05），提高胰岛素敏感性（P<0.05），改善糖耐量（P<0.05），并有一定调节血脂的作用，且降低空腹血糖较西药组更明显（P<0.05）。结论：降糖消渴颗粒联合二甲双胍可改善2型糖尿病小鼠的糖脂代谢，较单用二甲双胍能更有效地降低体重和血糖。 |
| English Summary: |
| To investigate the effect of Jiangtang Xiaoke granule(JTXKG)combined with metformin on the blood glucose and blood lipids in type 2 diabetic mice.Methods:ICR mice were fed by high-fat-diet for 4 weeks，combined with intraperitoneal injection of streptozocin in 100mg·kg-1.The mice were randomly divided into normal group，model group，western medicine group(metformin)and combination groups(JTXKG，combined with metformin，in low，medium，and high dose).After 4-week treatment，the body weight，fasting blood glucose(FBG)，fasting serum insulin(INS)，glucagon，and blood lipid(BL)were tested，and the glucose tolerance was measured.Results:Compared with model group，combination groups lost body weight(P<0.05)，decreased FBG(P<0.01)，INS(P<0.05)and glucagon(P<0.05)，improved glucose tolerance(P<0.05)，and showed certain BL changes.Compared with western medicine group，combination groups FBG were lower(P<0.05).Conclusion:JTXKG combined with metformin showed glucose and lipid metabolism improvement，and was more effective in weight loss and blood glucose reduction than metformin alone. |
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