To observe the effect of silybin particle dispersion on CCI4 induced acute liver injury and to provide support for its clinical usage. Methods:To make acute liver injury models by CCI4 and then compared the differences of ALT AST, SOD, HYP, GSH-PX in blood and liver in the normal group, model group, low dose group, middle dose group, high dose group, super high dose group, and the crude powder group. Results:ALT AST, SOD, HYP, GSH-PX in the middle and crude powder group were of no significant difference. ALT, AST, HYP in the super-high and blank control group were of no significant difference. Conclusion:The preventive effect of liver fibrosis were equivalent between the 1/10 original powder dosage of silybin particle dispersion by intravenous administration and in the crude powder dosage, which illustrated that silybin particle dispersion by intravenous administration can reduce the single and the total administration dosage and the degree of resistance to the body. Besides, it indicated that the intravenous administration, 40 mg·kg-1, prevention of 7 days model mice were largely unaffected by CCl4 and their liver resistance capability were improved. |