世界中医药

目的：分析电针治疗变应性鼻炎的临床疗效及对患者免疫功能的影响。方法：将本院2009年1月至2013年4月75例常年性变应性鼻炎患者纳入研究，并根据治疗方案分为常规组37例及电针组38例，所有患者尽量避免接触过敏原，常规组患者接受常规曲安奈德鼻喷剂法，1次/d，患者接受与对照组相同的常规治疗方法，同时接受电针迎香穴、鼻通穴、印堂穴、攒竹穴、足三里穴治疗，2组均连续治疗1年，比较治疗前后患者鼻部症状评分、T淋巴细胞亚群、免疫球蛋白IgA、IgG、IgM的变化。结果：1）经过治疗后对照组临床总有效率为72.97%，电针组临床总有效率为92.11%，2组比较差异有统计学意义（P<0.05），电针组优于对照组。针对临床症状评分方面，2组治疗后临床症状平均均有所下降，其中电针组下降的趋势更为明显；2）与治疗前比较，2组患者治疗后的CD4、CD4/CD8和NK细胞均显著升高，CD8细胞表达显著降低(P<0.01)；2组患者治疗后相比，电针治疗组患者的CD4、CD4/CD8和NK细胞显著高于对照组，但是CD8细胞显著低于对照组(P<0.01)；3）与治疗前比较，2组治疗后患者的IgA、IgG、IgM表达水平均明显降低(P<0.05)；2组患者治疗后相比，电针组的IgA、IgG、IgM表达水平明显低于对照组(P<0.05)。结论：电针能有效治疗变应性鼻炎的机制，与改善患者T细胞亚群及NK细胞以及体液免疫水平，提高机体免疫力相关。

English Summary:

to analyze the clinical curative effect of electroacupuncture treatment on allergic rhinitis and its influence on immune function of patients. Methods: 75 patients with perennial allergic rhinitis in our hospital during January 2009 to April, 2013 were included in the study. They were divided into the conventional group (37 cases) and the electroacupuncture group (38 cases) according to the treatment scheme. All patients avoided the exposure to allergens. Patients of the conventional group received triamcinolone acetonide nasal spray method, once a day; the patients of the electroacupuncture group received the same as the control group of conventional therapy, at the same time accepted electroacupunctured on the acupuncture points at Yingxiang point, Tongbi point, Yintang point, Chuanzu point and Zusanli point. Both of the groups were treated continuously for 1 year. The study compared the changes in patients of nasal symptom scores, T lymphocyte subpopulation and immunoglobulin IgA, IgG, IgM before and after treatment. Results: 1) After the treatment, the clinical total effective rate of the control group was 72.97%; the clinical total effective rate of the curative group was 92.11%. The comparison of the two groups was with statistically differences (P< 0.05) with the electroacupuncture group superior to the control group. The clinical symptoms of the two groups relieved after treatment on the clinical symptom scores, which the downward trend in electroacupuncture group was more obviously. 2) Compared with before the treatment, CD4, CD4/CD8 and NK cells significantly increased, and CD8 cells significantly reduced in the patients of the two groups after treatment (P<0.01). Comparing the patients of the two groups after treatment, CD4, CD4/CD8 and NK cells of the patients of the electroacupuncture group were significantly higher than the control group, but CD8 cells was significantly lower than that of the control group (P<0. 01); 3) Compared with before the treatment, IgA, IgG, IgM expression levels of the patients of the two groups were significantly lower after treatment (P<0.05). Comparing patients of the two groups after treatment, the expression level of IgA, IgG, IgM in electroacupuncture group was lower than that in the control group (P<0.05). Conclusion: Electroacupuncture is effective in treating allergic rhinitis. It is relevant to the improvement of T cell subsets, NK cells and humoral immune level in the patients and the immunity-improving of organism.

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