This paper analyzed the research progress of combination of the effective medicinals of Chinese Materia Medica(CMM) including both the direct combined form and the combination form based on the prescriptions efficacy, to point out CMM effective medicinals combination model is an important way for the studies on pharmacological effect substances and combination theories of prescriptions, which would be of great significance for creating a new combination of effective CMM that is relatively specific, the mechanism is clear. This paper clarified the problems existing in the research, strengthened the combination theories and pharmacological mechanisms of CMM to guide the effective medicials combination study. It is also pointed out that effective components or ingredients of CMM from the classic prescription, multidisciplinary collaboration, researches for appropriate patterns and methods for the study of effective medicinal combination would be important ways to develop medicials combination.