| 引用本文:胡国恒1，刘侃2，王瑾茜2，李映辰2，曾勇2，刘旺华3.肾脑复元汤对MCAO大鼠HGF及TGF-β表达的影响[J].世界中医药,2016,(04):. |
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| 肾脑复元汤对MCAO大鼠HGF及TGF-β表达的影响 |
| The Effects of Shennao Fuyuan Decoction on Expression of HGF and TGF-β in Middle Cerebral Artery Occlusion Rats |
| 投稿时间：2016-03-24 |
| DOI：10.3969/j.issn.1673-7202.2016.04.005 |
| 中文关键词: 肾脑复元汤 缺血性中风 肝细胞生长因子 转化生长因子-β |
| English Keywords:Shennao Fuyuan Decoction Ischemia stroke HGF TGF-β |
| 基金项目:国家自然科学基金项目（编号：81273751；81573941；81373702；81473567）湖南省研究生科研创新项目（编号：CX2015B315；CX2015B326） |
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| 中文摘要: |
| 目的：探究肾脑复元汤对MCAO大鼠脑保护作用及其机制。方法：72只SD大鼠随机分为假手术组、模型组、肾脑复元汤组，根据处死时间每组再随机分为3 d、7 d、14 d 3个亚组。比较各组大鼠神经功能缺损评分、脑梗死体积、神经营养因子HGF及TGF-β表达。结果：与模型组比较，肾脑复元汤组大鼠神经功能缺损评分明显下降（P<0.01），脑梗死体积明显缩小（P<0.01），缺血侧脑组织HGF及TGF-β表达明显增加（P<0.01）。结论：肾脑复元汤可以明显改善MCAO大鼠神经功能缺损症状，并促进脑梗死组织修复，其机制可能是通过促进HGF、TGF-β的表达。 |
| English Summary: |
| To investigate the neuroprotective mechanisms of Shennao Fuyuan Decoction.Methods:Total 72 SD rat were randomly assigned into three groups: sham operation group (sham group), middle cerebral artery occlusion model group (model group), Shennao Fuyuan Decoction group (SFD group). According to the executing time of 3, 7, 14days, rats in every group were divided into three sub groups. Comparison of all groups were performed based on Neurological Severity Scores(NSS), the volume of cerebral infarction, the expression of HGF and TGF-β.Results:NSS and the volume of cerebral infarction of SFD group were significantly lower (P<0.01), the expression of HGF and TGF-β were obviously higher(P<0.01).Conclusion:Shennao Fuyuan Decoction can alleviate the neurological defects and improve the reparation of injured brain, this neuroprotective effect is probably due to the suppression of inflammatory and promotion of HGF and TGF-β expression． |
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