| 引用本文:李开慧1，陈慧永2，傅娇3，王霞1，吴海霞1.复方丹参注射液联合硫酸镁对妊娠高血压综合征患者妊娠结局及ET、NO的影响[J].世界中医药,2016,(04):. |
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| 复方丹参注射液联合硫酸镁对妊娠高血压综合征患者妊娠结局及ET、NO的影响 |
| The Effect of Fufang Danshen Injection Combined with Magnesium Sulfate on Pregnancy Outcome in Patients with Hypertension and ET syndrome of NO |
| 投稿时间：2015-10-26 |
| DOI：10.3969/j.issn.1673-7202.2016.04.017 |
| 中文关键词: 复方丹参注射液,妊娠高血压,妊娠结局,ET及NO |
| English Keywords:Fufang Danshen injection Gestational hypertension Pregnancy outcome ET and NO |
| 基金项目:佛山市医学类科技攻关项目—“热敏灸联合中药治疗排卵功能障碍不孕症的临床研究”（编号:0007027120408032） |
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| 中文摘要: |
| 目的:探讨复方丹参注射液联合硫酸镁对妊娠高血压综合征患者的临床疗效。方法:选择在本院就诊的中轻度妊娠高血压患者90例，按随机数字列表法将其分为治疗组和对照组，每组各45例患者，对照组采用常规的西医治法，根据临床症状采用解痉、镇静、降压、利尿等治疗，治疗组在对照组治疗的基础上加复方丹参注射液治疗。1个疗程为时2周，治疗1个疗程后检查2组孕妇治疗前后血中ET及NO的变化情况，观察2组母儿的结局。结果:治疗后治疗组孕妇血浆内皮素因子（ET）下降的幅度较对照组明显，血浆一氧化氮（NO升高的幅度较对照组明显，P<0.05,对比有统计学意义；母婴结局对比：治疗组在胎心率异常、剖宫产、新生儿窒息、死胎等方面均低于对照组，P<0.05,对比有统计学意义。结论:复方丹参注射液联合硫酸镁治疗妊娠高血压的临床疗效确切,可能的作用机制是通过改变ET和NO的平衡来调节血压,从而减少胎心异常、死胎、新生儿窒息、剖宫产的发生率,具有临床推广价值。 |
| English Summary: |
| To investigate the clinical efficacy of Fufang Danshen injection combined with magnesium sulfate on patients with pregnancy induced hypertension syndrome. Methods: Ninety patients in our hospital were randomly divided into a observation group and a control group, with 45 patients in each. The control group was given conventional western medical treatment. The observation group was given a plus Fufang Danshen Injection. The treatment course was two weeks. Record the changes in blood ET(endothelin) and NO(nitric oxide) of the two groups, besides, the mother and child situation were observed after treatment. Results: After treatment, the decrease level of ET in the observation group is greater than that of the control group, and the increase level of NO is also greater in the observation group, and the differences are statistically significant(P<0.05). Maternal and neonatal outcomes comparison shows that in fetal heart rate abnormalities, caesarean section, neonatal asphyxia, stillbirth aspects, the observation has lower level than the control group, with P<0.05. Conclusion: Fufang Danshen injection combined with magnesium sulfate has high efficacy in treating pregnancy induced hypertension syndromes. The possible mechanism might be balancing ET and NO to regulate blood pressure, thereby reducing abnormal fetal heart rate, incidence of stillbirth, neonatal asphyxia, and caesarean section. It is worthy of clinical promotion. |
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