世界中医药

目的：通过五苓散治疗家兔腹泻模型实验,分析中医文献中“利小便所以实大便”的实质，阐明肾和小肠在水液代谢中的作用。方法：将30只家兔随机分为正常对照组、模型对照组、五苓散组，每组10只。正常对照组给予10 mL生理盐水，分2次灌胃；模型对照组和五苓散组以8%番泻叶粉混悬液一次性灌胃，腹泻潜伏期为（1.22±0.26） h；五苓散组灌胃番泻叶1.5 h后，给予五苓散方药灌胃。药物处理结束后，观察各组家兔血清BUN与Scr、PSP排泄率、小肠吸收能力、空肠平滑肌张力与收缩频率。结果：五苓散组和模型对照组血清BUN与Scr、PSP排泄率，以及空肠平滑肌张力与收缩频率存在显著统计学意义(P<0.05)，而小肠吸收能力差异无统计学意义(P<0.05)。结论：五苓散“小便作用而实大便”的作用是通过同时影响肾功能和小肠运动功能来实现的，而与小肠的吸收功能无关，因此传统文献中关于小肠对水液代谢调节的论述更应该放到肾与小肠之间的关联中去理解。

English Summary:

To analyze the mechanism of “promoting urination to treat diarrhea” and discuss the functions of kidney and small intestine on fluid metabolism.Methods:A total of thirty rabbits were randomly divided into normal control group(10), model control group(10), and Wulingsan group(10). The normal control group was given 10 mL normal saline, which was given intragastrically twice. The model control group was given Wulingsan and 8% Folium Sennae powder at the same time, once, intragastrically. Incubation of diarrhea was (1.22±0.26)h. The observation group was given Folium Sennae powder firstly and after 1.5 h, Wulingsan was given. Then observe serum BUN and Scr, PSP, absorbing capability of small intestines, and the tension and contraction force of jejunum.Results:Compared with model control group, all levels are better in the observation group(P<0.05) except for the absorbing capability of small intestine(P>0.05).Conclusion:The mechanism of “promoting urination to treat diarrhea” originates from the the function of kidney and the movement of small intestine, and it has nothing to do with the absorbing capability of small intestine. Therefore, the function of fluid regulation of small intestine should be discussed from the angle of the correlation between kidney and small intestine.

查看全文查看/发表评论下载PDF阅读器