| 引用本文:苏日娜1，其达拉图2，布仁达来2.蒙药治疗慢性胰腺炎模型大鼠的实验研究[J].世界中医药,2016,(04):. |
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| 蒙药治疗慢性胰腺炎模型大鼠的实验研究 |
| Experimental study of Mongolian Medicine Treating Chronic Pancreatitis Rat Model |
| 投稿时间：2016-01-07 |
| DOI：10.3969/j.issn.1673-7202.2016.04.033 |
| 中文关键词: 蒙药 大鼠 DBTC 慢性胰腺炎 治疗 |
| English Keywords:Mongolian medicine Rats DBTC Chronic pancreatitis(CP) Treatment |
| 基金项目:国家自然科学基金资助项目(编号:81341096)——基于TNF-α信号转导通路蒙药给旺-9对非酒精性脂肪性肝病作用机制的研究,项目负责人:布仁达来 |
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| 中文摘要: |
| 目的:以蒙医整体观为指导,以辨证治疗为原则,验证阿木日-6、茹达-6、巴特尔-7等3剂蒙药对慢性胰腺炎(CP)模型大鼠的治疗作用,筛选治疗CP的有效药物。方法:大鼠随机分为六组,除对照组外其余各组大鼠尾静脉注射二氯二丁基锡(DBTC)溶液,对照组注射同等体积DBTC溶解液。造模第2 天起开始给药。造模14 d后验证模型。造模28 d后处死大鼠,行血清淀粉酶(AMS)、肿瘤坏死因子-α(TNF-α)含量检测、HE染色组织学观察。结果:对照组及各给药组大鼠一般情况明显好于模型组,AMS、TNF-α含量明显低于模型组(P<0.05);各给药组大鼠胰腺炎性细胞与纤维组织明显少于模型组。结论:大鼠尾静脉注射DBTC可成功制造CP模型。阿木日-6、茹达-6、巴特尔-7等3剂蒙药可有效降低血清AMS、TNF-α含量,减少胰腺损伤,对CP模型大鼠有良好的治疗作用。 |
| English Summary: |
| Taking Mongolian holistic concept as a guidance and dialectical treatment based on syndrome differentiation as a principle, to verify the effect of three Mongolian medicines to chronic pancreatitis (CP) model rats, AMURI-6, RUDA-6 and BATER-7 through pharmacological experiment and to select effective medicine to treat CP in clinic.Methods:80 Wistar rats were randomly divided into the 6 group. Rats in the model group and four dose groups were injected with Dibutyltin dichloride (DBTC) via the tail, and rats in the control group were injected with same amount of Dibutyltin dichloride solution via the tail. The model was made from the first day, and medicine was applied by intravenous administration twice a day. The model was tested14 days after modeling. All rats were put to death and sampled 28 days after modeling. Content of AMS and TNF-α were tested and HE staining histology was observed.Results:The general states of rats in the control group and the treatment groups were significantly better than those of rats in the model group. The levels of serum AMS and TNF-α of rats in the control group and the four treatment groups were significantly lower than those of rats in the model group (P<0.05). In the control group and the four treatment groups, the pathological evaluation，fibrosis degree and the extent of damage of the pancreas were significantly lower than those of the model group.Conclusion:The CP rat model made by injecting Dibutyltin dichloride (DBTC) via the tail was proved to be successfully set. Mongolian medicines, AMURI-6, RUDA-6 and BATER-7, may have the function of recovering part of pancreatic gland alveolus of the model group and reducing fibrous tissue among lobule. These medicines are effective for CP, which has a high clinical value in the treatment. |
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