| 引用本文:哈略1，刘耀萌1，于梦芸1，崔莹雪2，赵百孝1.艾灸及艾烟对APOE基因敲除小鼠血清促炎因子的干预研究[J].世界中医药,2016,(04):. |
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| 艾灸及艾烟对APOE基因敲除小鼠血清促炎因子的干预研究 |
| Influence of Moxibustion and Moxa Smoke on Proinflammatory Factors in ApoE Knock-out Mice |
| 投稿时间：2015-12-10 |
| DOI：10.3969/j.issn.1673-7202.2016.04.036 |
| 中文关键词: 艾灸 APOE-/-小鼠 动脉粥样硬化 促炎因子 |
| English Keywords:Moxibustion ApoE knock-out mice Atherosclerosis Pro-inflammatory factors |
| 基金项目:国家重点基础研究发展计划(“973”计划)项目(编号:2009CB522906);国家自然科学基金项目(编号:81373730) |
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| 中文摘要: |
| 目的:观察艾灸及艾烟对APOE-/-小鼠血清细胞间黏附分子(ICAM1)、血管细胞黏附分子(VCAM1)以及单核细胞趋化因子(MCP-1)水平的影响,以期初步探讨艾灸防治动脉粥样硬化的机制。方法:采用高脂饮食喂养的载脂蛋白E基因敲除小鼠(APOE-/-小鼠)作为动脉粥样硬化模型,并随机分为4组:艾灸组、艾烟组、香烟对照组组、模型组。分别运用艾灸、艾烟及香烟的方式进行干预,干预12周后观察小鼠血清ICAM1、VCAM1及MCP-1水平的变化。结果:与模型组相比,艾灸组,艾烟组小鼠血清ICAM1、VCAM1及MCP-1水平明显降低(P<0.05),艾灸组,艾烟组之间无统计学意义。香烟组于模型组之间差异无统计学意义。结论:艾灸及艾烟可明显降低动脉粥样硬化小鼠血清中黏附分子和单核趋化分子的水平。 |
| English Summary: |
| To study the influence of moxibustion and moxa smoke on serum VCAM-1, ICAM-1 and MCP-1 levels of ApoE knockout mice, so as to investigate the potential mechanism of moxibustion treating atherosclerosis.Methods:Atherosclerosis model was established by ApoE gene knock-out mice with high-fat diet feeding. The mice were randomly divided into the model group, moxibustion group, moxa smoke group and cigarette smoke group. After 12 weeks interference, the levels of VCAM-1, ICAM-1 and MCP-1 in the mice serum were measured.Results:Compared with the model group, the serum VCAM-1, ICAM-1 and MCP-1 levels of moxibustion group and moxa smoke group were decreased significantly（P<0.05). There is no significant difference between the moxibustion group and moxa smoke group. No significant difference was observed between cigarette smoke group and model group.Conclusion:Moxibustion and moxa smoke may obviously reduce serum VCAM-1, ICAM-1 and MCP-1 levels in atherosclerosis mice. |
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