To observe the improvement on quality life of chronic heart failure(CHF) patients with syndrome element differentiation treatment. Methods: Total 99 patients with CHF were randomly divided into two groups: treatment group and control group, both groups were given conventional treatment, Chinese medicine were treated with syndrome element differentiation on basis of western medicine treatment. Then the quality of life was observed with evaluating scale of the quality of life in chronic heart failure and SF-36. Results: Quality of life improved in both groups after the treatment(P<0.05), but no difference was shown between groups(P>0.05). Secondly, there was statistical difference on energy, social ability, emotional function and mental health between two groups (P<0.05), which means patients improved more in treatment group, while patients felt no difference on physical function, physical ability, body pain, general health after the treatment (P>0.05). Patients felt better in each group at following terms of physical function, body pain and social ability (P<0.05). While treatment group scored higher at some terms such as physical ability, general health, energy, emotional function after the treatment (P<0.05), but the control group were not (P<0.05). Conclusion: Treatment with syndrome element differentiation can improve the quality of life of patients with chronic heart failure.