| 引用本文:张云海，邓梦华，马明远.中医扶正祛邪法对脓毒性休克患者血流动力学的影响[J].世界中医药,2016,(05):. |
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| 中医扶正祛邪法对脓毒性休克患者血流动力学的影响 |
| Effect of Chinese Medicine’s Reinforcing Healthy Qi and Eliminating Pathogen Method on hemodynamics of patients with septic shock |
| 投稿时间：2016-01-11 |
| DOI：10.3969/j.issn.1673-7202.2016.05.019 |
| 中文关键词: 扶正祛邪 参芪扶正注射液 血必净注射液 脓毒性休克 血流动力学 |
| English Keywords:Fuzhengquxie Shenqifuzheng injection Xuebijing injection Septic shock Hemodynamics |
| 基金项目:佛山市卫生和计划生育局医学科研课题(编号:20160036)——“扶正祛邪法对脓毒性休克患者炎性反应因子及免疫功能影响的临床研究” |
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| 中文摘要: |
| 目的:观察中医扶正祛邪法对脓毒性休克患者血流动力学的影响,探讨其作用机制。方法:78例脓毒性休克患者随机分成对照组(37例)和中医干预组(41例)。对照组患者按照脓毒症指南集束化治疗,中医干预组在对照组的基础上予参芪扶正注射液联合血必净注射液静滴治疗。测定治疗前后的血清乳酸值(Lac)、心指数(CI)和血管外肺水含量指数(EVLWI),统计2组患者缩血管药物使用时间、急性生理与慢性健康评分(APACHEII评分)、ICU住院时间和28 d死亡率。结果:2组患者治疗后Lac水平均较前下降,而中医干预组下降更显著(P<0.05)。2组CI较治疗后均有升高,中医干预组提升较对照组明显(P<0.05)。中医干预组EVLWI和ITBVI较前明显改善,而对照组治疗前后改善不明显,中医干预组与对照组比较差异具有统计学意义(P<0.05)。中医干预组在缩血管药物使用时间、住ICU时间均较对照组要短(P<0.05),比较差异具有统计学意义。而2组患者的治疗后APACHEII评分均治疗前下降,但中医干预组较对照组下降更显著(P<0.05)。2组患者28 d死亡率比较差异无统计学意义(P>0.05)。结论:中医扶正祛邪法可改善脓毒性休克患者血流动力学和患者的病情,并缩短ICU住院时间。 |
| English Summary: |
| To observe the effect of Chinese medicine’s Reinforcing Healthy Qi and Eliminating Pathogen Method on hemodynamics of patients with septic shock and to explore its mechanism. Methods: Total 78 patients with septic shock were randomly divided into control group (37 cases) and Chinese medicine intervention group (41 cases). The control group’s patients were treated with sepsis bundles therapy according to the treatment guidelines and Chinese medicine intervention group with Shenqi Fuzheng Injection Combined with Xuebijing Injection by intravenous drip on the basis of the control group’s treatment. The serum lactic acid (LAC), cardiac index (CI) and extravascular lung water content index (EVLWI), reduced vascular drug use time of the two groups, acute physiology and chronic health score (APACHE II score), length of stay in the ICU and 28-day mortality were recorded before and after the treatment. Results: The levels of Lac of the two groups dropped after the treatment, and the result of Chinese medicine group was more significant (P<0.05). CI of the two groups rise after the treatment, the improvement of Chinese medicine intervention group was significantly higher than that of the control group (P<0.05). EVLWI and ITBVI of Chinese medicine intervention group had significant improvement, while the control group had no obvious effect, the differences were statistically significant (P<0.05). The use of reduced blood vessel drugs, live ICU time of Chinese medicine were shorter than the control group, with significant statistical differences (P<0.05). APACHEII scores of the two groups decreased after treatment, but the Chinese medicine intervention group decreased more significantly (P<0.05). There was no significant difference in mortality rate between the two groups (P>0.05). Conclusion: Chinese medicine’s Reinforcing Healthy Qi and Eliminating Pathogen Method can improve the pus toxic shock hemodynamics and relieve patients’ symptoms, so as to shorten the time of ICU stay. |
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