| 引用本文:赵为民，刘林，方法，杨新辉，王海江.黄芪注射液对Ⅲ期胃癌的疗效及对机体免疫功能的影响[J].世界中医药,2016,(06):. |
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| 黄芪注射液对Ⅲ期胃癌的疗效及对机体免疫功能的影响 |
| The Effect of Huangqi Injection on Stage III Gastric Carcinoma and its Function on Body’s Immunity |
| 投稿时间：2015-12-21 |
| DOI：10.3969/j.issn.1673-7202.2016.06.011 |
| 中文关键词: Ⅲ期胃肿瘤 黄芪注射液 Th1/Th2 |
| English Keywords:Stage III gastric carcinoma Huangqi injection Th1/Th2 ratio |
| 基金项目:新疆卫生厅医疗卫生科研计划项目(编号:2010075) |
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| 中文摘要: |
| 目的:观察黄芪注射液对Ⅲ期胃癌的疗效,并探讨其对机体免疫功能的影响。方法:将我院2008年1月至2010年11月60例Ⅲ期胃癌患者随机分为对照组和观察组,并将同期30例健康体检者设为健康对照组。2组Ⅲ期胃癌均接受胃癌根治术,并在术后常规给予化疗,以30 d为1个疗程,观察组在常规治疗基础上加用黄芪注射液30 mL加入0.9%氯化钠溶液250 mL中静脉滴注,1次/d,连续治疗30 d。治疗结束后2组胃癌患者的生活质量(Karnofsky评分)及累积生存率。检测3组患者外周血Th1、Th2细胞百分比变化。结果:1)黄芪注射液可以明显提高Ⅲ期胃癌患者的生活质量,同时提高患者的累积生存率。2)胃癌患者Th1/Th2比值明显低于健康对照组,经过治疗后2组患者Th1/Th2比值均有所下降,其中观察组下降的趋势更明显(P<0.05)。结论:Ⅲ期胃癌患者体内出现CD4+T细胞平衡失调,黄芪注射液可以通过纠正CD4+T细胞的水平达到提高患者生活质量的目的。 |
| English Summary: |
| To observe the curative effect of Huangqi injection on stage III gastric cancer and its effects on the body’s immune function.Methods:A total of 60 patients in stage III gastric carcinoma admitted in our hospital during January 2009 to January 2014 were randomly divided into the control group and the observation group.Also,30 cases of healthy people were recruited as healthy control group.Both of the two groups had received radical operation and took the conventional EOF scheme chemotherapy after surgery.The observation group was given Huangqi injection 30 mL with 250 mL 0.9% sodium chloride solution by intravenous drip on the basis of conventional treatment,1 time/ day,20 days.After treatment,compared the two groups in the aspects of quality of life (Karnofsky score),peripheral blood mononuclear cells,and the accumulative survival rate.Detected the peripheral blood Th1,Th2,and the cell percentage change of the three groups.Results:1) Huangqi injection could obviously increase the quality of life in the patients in stage III gastric cancer,and simultaneously increase the accumulative survival rate of the patients.2) Th1/Th2 ratio in the patients with gastric cancer was significantly lower than that of the healthy control group.However,Th1/Th2 ratio of the two groups both decreased after treatment,and the descending trend in the observation group was more obvious (P<0.05).Conclusion:For patients in stage III gastric carcinoma,CD4+T cells are abnormal and Huangqi injection can improve the quality of the patients’ life by regulating the levels of CD4+T cells. |
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