To study the efficacy of Fuzheng Yiliu Formula and psychological intervention on the living quality of patients with advanced breast cancer. Methods:The patients who met the inclusive criteria were divided into the treatment group and control group. The treatment group were given Fuzheng Yiliu Formula and psychological intervention, and the control group were only treated with Fuzheng Yiliu Formula. The emotion such as depression and anxiety was measured at baseline after three and six months’ treatment. Result: SDS and SAS of the both groups dropped after the treatment. There were significant differences compared with the scores of the patients before the treatment (F=4.124, P=0.045; F=4.288, P=0.041), and there were also significant differences in the score of emotion between the treatment group and the control group at three months and six month (F=5. 321, P=0.023; F=16.859, P<0. 001；F=4.320, P=0.040; F=16.610, P<0. 001). Conclusion:Fuzheng Yiliu Formula and psychological intervention can effectively relieve the depression and anxiety of the patients.