| 引用本文:谢皛，张大炜.活血通络方干预不稳定型心绞痛的临床疗效[J].世界中医药,2016,(06):. |
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| 活血通络方干预不稳定型心绞痛的临床疗效 |
| Clinical observation of Activating-blood and Tong Luo Fomula on Unstable Angina Pectoris and Its Impacts on High Sensitive C-reactive Protein (hs-CRP) and Lipoprotein-associated Phospholipase A2(Lp-PLA2) |
| 投稿时间：2016-01-11 |
| DOI：10.3969/j.issn.1673-7202.2016.06.015 |
| 中文关键词: 活血通络方 不稳定型心绞痛 疗效 hs-CRP Lp-PLA2 |
| English Keywords:Blood-activating and collaterals-dredging Formula Unstable angina pectoris Clinical effects hs-CRP Lp-PLA2 |
| 基金项目:首都中医药研究专项基金(编号:13EY12) |
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| 中文摘要: |
| 目的:观察活血通络方治疗冠心病不稳定型心绞痛(UAP)的临床疗效及对血浆高敏C反应蛋白(hs-CRP)和脂蛋白相关磷脂酶A2(Lp-PLA2)的影响。方法:52例UAP患者随机分为对照组26例和治疗组26例。对照组给予常规治疗,治疗组加服中药活血通络方,1个疗程为8周。观察临床症状和心电图,测定治疗前后高敏C反应蛋白(hs-CRP)和脂蛋白相关磷脂酶A2(Lp-PLA2)的变化情况。结果:治疗组心绞痛和心电图总有效率为92.3%和84.6%,均明显较高于对照组的73.1%和61.5%(P<0.05);治疗后治疗组Lp-PLA2及hs-CRP均显著下降,且均优于对照组(P<0.05)。结论:活血通络方对UAP具有良好辅助治疗作用,其部分机制与降低Lp-PLA2和hs-CRP,减轻炎性反应有关。 |
| English Summary: |
| To observe the clinical effects of Blood-activating and collaterals-dredging Formula on the treatment of unstable angina pectoris (UAP),and its impacts on high sensitive C-reactive protein (hs-CRP) and lipoprotein-associated phospholipase A2(Lp-PLA2).Methods:A total of 52 patients with UAP were randomly divided into control group (26 cases) and study group (26 cases).The control group received conventional treatment; the study group was treated with Blood-activating and collaterals-dredging Formula additionally on the basis of the control group.Both were treated for 8 weeks.The clinical symptoms and cardiographs were observed,the contents of Lp-PLA2 and high sensitive C-reactive protein (hs-CRP) in serum were determined before and after treatment.Results:The clinical efficiency of angina pectoris and cardiograph was 92.3% and 84.6%,respectively in study group,both were higher than the control group (73.1% and 61.5%,respectively) (P<0.05); the contents of Lp-PLA2 and CRP decreased greatly (P<0.05),and there were significant differences between two groups (P<0.05).Conclusion:Blood-activating and collaterals-dredging Formula is suitable for treating UAP,partly because of its function of lowering the contents of Lp-PLA2 and hs-CRP,as well as alleviating inflammation. |
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