世界中医药

目的：观察采用中西医结合治疗对白癜风的临床疗效和血清炎性因子的影响。方法：选择本院2014年2月至2016年2月收拾的110例白癜风患者为研究对象，将患者随机分为2组，每组55例患者。对照组给予患者常规的西医方案治疗，予以口服药物和涂抹药物治疗方案。观察组在常规西医方案治疗的基础上加用中药治疗。4周为1个疗程，2组均给予2个疗程的治疗。观察对比2组患者治疗前后的临床疗效、不良反应、白细胞介素-17（IL-17）、血清中肿瘤坏死因子-α（TNF-α）和γ-干扰素（IFN-γ）水平。结果：经过8周的治疗后，对照组总有效率为76.36%，观察组总有效率为87.27%，差异有统计学意义；2组患者血清IL-17、IFN-γ和TNF-α水平都有了不同程度的降低，观察组下降更显著，差异有统计学意义（P<0.05）。2组患者均无明显不良反应。结论：中西医结合治疗能够有效的调节白癜风患者免疫功能，降低患者的血清IL-17、IFN-γ和TNF-α水平，临床疗效好，安全性高，值得临床推广。

English Summary:

To investigate clinical efficacy of Chinese and western medicine in vitiligo and their effects on the serum inflammatory factors.Methods:Vitiligo patients of 110 cases in our hospital from February 2014 to February 2016 were randomly divided into two groups,each group had 55 cases.The control group received routine western medicine by oral medication and apply salves,the observation group additionally received Chinese medicine for treatment prescription.One course of treatment was four weeks,both groups were observed for two courses of treatment.Clinical efficacy,adverse reactions,interleukin-17(IL-17),Tumor necrosis factor(TNF-α),Interferon gamma(IFN-γ) were compared before and after treatment.Results:After 8 weeks’ treatment,the total effective rate of the control group was 76.36%,while in the observation group,the total effective rate was 87.27%,the difference was statistically significant（P<0.05＝；serum levels of interleukin-17(IL-17),Tumor necrosis factor(TNF-α),Interferon gamma(IFN-γ) decreased significantly in two groups compared with those before treatment(P<0.05＝;no obvious adverse reactions in the two groups.Conclusion:Integrated Chinese medicine and western medicine treatment can regulate body immune function,lower serum IL-17,IFN-γ and TNF-α levels,which has good clinical results and high safety.It is worthy of clinical application.

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