| 引用本文:黄世敬，张颖，王联生.基于神经血管单元的中医药抗抑郁靶向思考[J].世界中医药,2016,(06):. |
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| 基于神经血管单元的中医药抗抑郁靶向思考 |
| Discussion on the Anti-depression Target of TCM Herbs Based on Neurovascular Unit |
| 投稿时间：2015-11-13 |
| DOI：10.3969/j.issn.1673-7202.2016.06.043 |
| 中文关键词: 抑郁症 神经血管单元 中医治法 |
| English Keywords:Depression Neurovascular unit TCM therapy |
| 基金项目:国家自然科学基金项目（编号：81573790;81072801）；北京市科技计划（编号：Z141100002214014、Z161100001816013）；中央级公益性科研院所基本科研业务费专项（编号：ZZ0708076） |
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| 中文摘要: |
| 文章旨在探讨抑郁症神经血管单元稳态失衡的中医药干预思路。通过对抑郁症神经血管单元（NVU）稳态变化的发病机制分析，将中医理论和现代医学研究成果相结合，提出气血并治，神经与血管兼顾；培元开郁，靶向神经血管单元的总体思路。重点论述了抑郁症神经血管单元稳态变化的关键环节，从而提出益气化痰解郁，调血脑屏障，维护NVU微环境；培元活血治郁，建神经血管耦联，复NVU基本结构；固本解毒开郁，抗神经炎症反应，保护NVU组成元件。总之，靶向神经血管单元，应充分体现中医整体观和辨证论治原则。 |
| English Summary: |
| This paper aims to investigate the TCM intervention in the imbalance of neurovascular unit (NVU) homeostasis in depression patients.Through the analysis of the pathogenesis of homeostasis changes of the NVU in depression and combination of TCM theory and modern medical researches,this paper proposed the general intervention ideas:simultaneous treatment of qi and blood,simultaneous consideration of both nerves and blood vessels and benefiting the original qi and relieving stagnation then target to the NVU.Focused on the key links of the NVU homeostasis changes in depression,this paper suggested to tonify qi and reduce phlegm to treat depression,adjust the blood brain barrier to maintain the NVU micro-environment,reinforce the vital essence and activate blood to treat depression,build the neural vascular coupling to reconstruct NVU basic structure,consolidate the constitution and detoxicate to relieve depression,resist nerve inflammation to protect the NVU components.In conclusion,the target to the NVU should sufficiently manifest the principle of the holistic and differential treatment of TCM. |
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