| 引用本文:翁志军1，王立东1，季亚婕1,2，谭琳蓥1，谢恒如1，刘慧荣1，吴焕淦1.NMDA受体NR2B亚基在慢性内脏痛敏及针灸治疗中的作用[J].世界中医药,2016,(06):. |
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| NMDA受体NR2B亚基在慢性内脏痛敏及针灸治疗中的作用 |
| Effects of NR2B Subsets of NMDA Receptor in Acupuncture Treatment For Chronic Visceral Pain |
| 投稿时间：2015-06-10 |
| DOI：10.3969/j.issn.1673-7202.2016.06.048 |
| 中文关键词: NMDA受体 NR2B 内脏痛 针灸 |
| English Keywords:NMDA receptor NR2B Visceral pain Acupuncture |
| 基金项目:国家自然科学基金项目(编号:81202752);国家重点基础研究发展计划(“973”计划)项目资助(编号:2015CB554500);上海市卫计委项目资助(编号:20144Y0227) |
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| 中文摘要: |
| N-甲基-D-天门冬氨酸(N-methyl-D-aspartate,NMDA)受体具有多种不同亚基,且在中枢分布不同,N-甲基-D-天门冬氨酸受体(N-methyl-D-aspartate receptor,NMDAR)参与体内各种信号的传递和调节神经元的兴奋性,如介导躯体和内脏疼痛的发生和发展,NMDA受体中NR2B亚型与疼痛相关机制研究关系最为密切,内脏痛(Visceral Pain)是临床常见的症状,主要是由于各脏器及胸腹壁层的感觉神经末梢受到强烈机械、化学刺激,也可由局部缺血、平滑肌痉挛及代谢产物不能及时排除而引起的疼痛感觉。电针在内脏痛的临床治疗中疗效肯定,实验研究发现电针对中枢NMDA受体尤其是NR2B亚基具有调控作用,初步揭示了电针镇痛又一潜在靶点,本文就NR2B亚基的结构、功能、参与慢性内脏痛的机制,以及近些年针灸治疗慢性内脏痛的机制研究进行概述。 |
| English Summary: |
| N-methyl-D-aspartate receptor (NMDAR) has a variety of different subsets that are located differently on the central nerve.It involves in the transmission of signals in the body and regulates the excitability of neurons,such as mediating development of somatic and visceral pain.The NR2B subset of NMDAR is mostly common researched in its pain-related mechanism.Also,visceral pain is a common clinical symptom,which was induced by mechanical and chemical stimulation to the sensory nerve endings of the organs and chest and abdominal walls or local ischemia,smooth muscle spasm and retained metabolite.Electric acupuncture was proved to have significant effect in the treatment of visceral pain and studies found that electric acupuncture can regulate NMDA receptors,especially NR2B subset,revealing a potential analgesia target of electric acupuncture.This article analyzed the structure,function,and mechanism of NR2B subset and discussed its mechanism in reliving chronic visceral pain on the basis of the TCM (traditional Chinese medicine) researches in this field in recent years. |
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