| 引用本文:靳秀明，郭晓芳，刘侠，宋智慧.柔脉法对颈动脉粥样硬化患者血清TNF-α及Fg的影响[J].世界中医药,2016,(07):. |
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| 柔脉法对颈动脉粥样硬化患者血清TNF-α及Fg的影响 |
| Effects of Soften Vessel Medicine on the Content of TNF-α and Fg in the Serum of Patients with Carotid Αtherosclerosis |
| 投稿时间：2015-08-17 |
| DOI：10.3969/j.issn.1673-7202.2016.07.020 |
| 中文关键词: 柔脉法 参芪柔脉合剂 颈动脉粥样硬化 TNF-α Fg |
| English Keywords:Soften vessel medicine Shenqi Roumai decoction Carotid atherosclerosis TNF-α Fg |
| 基金项目:河北省中医药管理局中医药类科研计划项目(编号:2014109) |
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| 中文摘要: |
| 目的:研究具有柔脉功用之参芪柔脉合剂对颈动脉粥样硬化患者血清肿瘤坏死因子α(Tumor necrosis factor-α,TNF-α)及纤维蛋白原(Fibrinogen,Fg)的影响,以探讨其抗动脉粥样硬化的作用机制。方法:将经彩色多普勒超声检查确诊为颈动脉粥样硬化的患者138例,随机分为治疗组和对照组。对照组给予辛伐他汀胶囊20 mg,1次/晚口服;治疗组加用参芪柔脉合剂100 mL,2次/d口服;2组均持续用药6个月后观察临床疗效。结果:与治疗前比较,2组治疗后颈动脉斑块积分均减少,血清TNF-α、Fg含量均降低;与对照组比较,治疗组治疗后颈动脉斑块积分以及血清TNF-α含量均显著降低。结论:具有柔脉功用之参芪柔脉合剂可显著调节颈动脉粥样硬化患者炎性细胞因子,通过抑制炎性反应损伤发挥抗颈动脉粥样硬化作用。 |
| English Summary: |
| To observe the effect of soften vessel medicine on the content of Tumor necrosis factor-α (TNF-α) and fibrinogen (Fg) in serum of patients with carotid atherosclerosis.Methods:A total of 138 cases of patients with carotid artery atherosclerosis diagnosed by Color Doppler ultrasound were randomly divided into treatment group(70 cases) and control group(68 cases). The treatment group was treated with Shenqi Roumai mixture 100 mL, twice/d, orally taken, and simvastatin 20 mL, once/day. The control group was treated with with simvastatin 20cm, once/day. The treatment course lasted for 6 months.Results:Compared with before treatment, the integration of plaque and the content of TNF-α and Fg in serum were decreased in both groups, and these are more obvious in the treatment group.Conclusion:Soften vessel medicine could regulate inflammation cytokine of the carotid atherosclerosis and inhibit carotid atherosclerosis by restraining inflammation damage. |
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