| 引用本文:赵雪松1，樊永平1，陈志刚2，高芳2.三七总皂苷对脑出血大鼠神经功能及脑含水量的影响[J].世界中医药,2016,(07):. |
|
| 三七总皂苷对脑出血大鼠神经功能及脑含水量的影响 |
| Panax Notoginseng Saponins′s Effect on Nerve Function and Cerebral Edema of Rats with Cerebral Hemorrhage |
| 投稿时间：2016-03-31 |
| DOI：10.3969/j.issn.1673-7202.2016.07.042 |
| 中文关键词: 三七总皂苷 脑出血 神经功能 脑含水量 |
| English Keywords:Panax Notoginseng Saponins Cerebral hemorrhage Nerve function Brain water content |
| 基金项目:北京市中医药科技项目(编号:QN2014-17);首都医科大学附属北京天坛医院青年科研基金(编号:2014-YQN-YS-06) |
|
| 摘要点击次数: 1254 |
| 全文下载次数: 1155 |
| 中文摘要: |
| 目的:研究三七总皂苷对脑出血大鼠神经功能及脑含水量的影响。方法:实验用健康Sprague-Dawley(SD)同系雄性大鼠350只,体重230~250 g,大鼠随机分为假手术组(简称CG),模型组(简称MG),用药组(简称TG)3个组,每组分6 h、24 h、48 h、72 h、7 d,5个时间点。造模用Ⅳ型胶原酶注入尾壳核,治疗组给予三七总皂苷腹腔注射,1次/d。在相应时间点,采用改良的神经功能缺损评分(Modified Neurological Severity Score,mNSS)对各时间点神经功能缺损进行评价。结果:各时间点MG mNSS和CG比明显升高,差异有统计学意义(P<0.05)，除6 h外,各时间点MG和TG比,TG mNSS明显降低,差异有统计学意义(P<0.05)。各时间点MG脑含水量和CG比明显升高,差异有统计学意义(P<0.05)，除6 h、7 d外,各时间点MG和TG比,TG脑含水量明显降低,差异有统计学意义(P<0.05)。结论:脑出血模型组中,6 h开始,mNSS和脑含水量明显增高,到48 h达到高峰,以后逐渐下降,三七总皂苷可以明显下调 mNSS评分和脑含水量。 |
| English Summary: |
| To investigate the effects of Panax Notoginseng Saponins (PNS) on the neurological function and cerebral water content in the rats with cerebral hemorrhage. Methods: A total of 350 healthy homologous male SD rats, 230~250 g, were randomly divided into control group, model group and treatment group, and were observed at the following time points: 6 h, 24 h, 48 h, 72 h and 7days respectively. Rats model was established by Ⅳ collagenase type uniform slowly into the tail putamen hemorrhage. The treatment group were given intraperitoneal injection of PNS once a day. The Modified Neurological Severity Score (mNSS) of each group at the same time points was used to evaluate the nerve damage. Results: The mNSS of model group was significantly higher at every time point than the control group (P<0. 05). Except for 6 h, the mNSS of treatment group was significantly higher at the other time points than the other two groups (P<0. 05). The brain water content of the model group was significantly higher at every time point than the control group (P<0. 05). Except for the 6 h and 7d time point, the brain water content of the treatment group was significantly lower than the other two groups (P<0. 05). Conclusion: In the cerebral hemorrhage model groups, the mNSS and brain water significantly increased at 6 h, reached a peak at 48 h, then gradually declined. PNS can significantly decrease the mNSS scores and brain water content. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
