To observe the clinical effect Self-made Bushen Tiaogan Zhichan decoction in treating Parkinson′s disease(PD). Methods: Total 70 PD patients were randomly divided into the control group(35 cases) and observation group(35 cases).The control group received madopar with placebo. The observation group received madopar added Bushen Tiaogan Zhichan decoction. The clinical effect after the treatment, dosage of madopar per day in treatment and scores of unified PD rating scale (UPDRS), Parkinson′s disease sleep scale(PDSS), Hamilton Depression scale(HAMD), Mini-Mental State Examination (MMSE), PD quality of life scale(PDQ-39), Chinese medicine syndrome scores, as well as the adverse effect were recorded before and after the treatment. Results: After one treatment course, the scores of the two groups improved, but the observation group had more obvious change(P<0.05）; six months after the treatment, the scores of the observation group changed little, but the the control group changed greatly (P<0.05）. when comparing the two groups at the same time period, the results of UPDRSⅠ-Ⅳ score, HAMD, PDQ-39, Chinese medicine syndrome scores in the observation group were lower than those in the control group(P<0.05）. the score of MMSE and PDSS in observation group were higher than control group(P<0.05）. The dosage of madopar in the observation group was less than the control group (P<0.05）; the total effective rate of the observation group was 85.7%, significantly higher than control group′s 57.1%(P<0.05）; the adverse reaction in the two group was not clear. Conclusion: Self-made Bushen Tiaogan Zhichan decoction can relieve motor and non-motor symptoms and improve patients′ quality of life, reduce the adverse effect, which is worthy of clinical promotion.