| 引用本文:李鹏英，吴婷婷，龙飞虎，孙燕，王旭.小柴胡汤拆方对慢性束缚抑郁模型大鼠脑组织神经递质的影响[J].世界中医药,2016,(08):. |
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| 小柴胡汤拆方对慢性束缚抑郁模型大鼠脑组织神经递质的影响 |
| Effect of Minor Bupleurum Decoction and its Disassembled Prescription on Brain Neurotransmitter in Rats with Chronic Depression Model |
| 投稿时间：2015-07-28 |
| DOI：10.3969/j.issn.1673-7202.2016.08.048 |
| 中文关键词: 小柴胡汤 拆方 抑郁症 单胺类神经递质 去甲肾上腺素 5-羟色胺 |
| English Keywords:Minor Bupleurum Decoction Disassembled prescription Depression Monoamine neurotransmitter Norepinephrine 5-hydroxytrytryptamine |
| 基金项目:国家中医药管理局中医药重点学科金匮要略学科 |
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| 中文摘要: |
| 目的：观察小柴胡汤及其各药对对抑郁模型大鼠脑组织单胺类神经递质的影响，探讨小柴胡汤及其各药配伍抗抑郁作用机制。方法：采用慢性束缚应激方法建立大鼠抑郁症模型，观察小柴胡汤对慢性应激抑郁模型大鼠的行为学改变，高效液相色谱法测定大鼠脑内单胺类神经递质的含量，评定小柴胡汤及各药对对抑郁动物模型的影响。结果：模型组大鼠脑内单胺类神经递质含量与正常组差异有统计学意义；全方组大鼠海马5-HT、NE、5-HIAA（5-HT的降解物）的含量明显升高；姜夏组、参草组大鼠海马NE含量显著升高；全方组、柴芩组、参草组大鼠海马5-HT含量显著提高；全方组、柴芩组、姜夏组大鼠海马5-HIAA含量极显著增高。结论：小柴胡汤治疗抑郁症有良好的疗效，各药对作用于模型大鼠脑组织神经递质的靶点有一定的偏向性。柴胡与黄芩配伍主要通过提高大鼠海马5-HT含量而发挥其抗抑郁作用；生姜与半夏配伍能显著提高大鼠海马NE含量，二者配伍虽然对抑郁大鼠海马5-HT的改变影响不显著，但能显著增加5-HT的降解物5-HIAA的含量；人参、甘草、大枣能显著提高抑郁大鼠脑内5-HT和NE含量。 |
| English Summary: |
| To observe the effect of Minor Bupleurum Decoction on monoamine neurotransmitters in brain tissue of rat model of depression, and to investigate the mechanism of antidepression of Minor Bupleurum Decoction. Methods: Rat model of depression built by chronic restraint stress was used to observe the behavioral changes of Minor Bupleurum Decoction. HPLC method was used to determine the content of monoamine neurotransmitters in brain of rats. And then the effects of Minor Bupleurum Decoction and other Chinese medicinals were evaluated on animal models of depression. Results: The contents of monoamine neurotransmitters, model group and the normal group were significantly different. The content of 5-HT, NE, 5-HIAA significantly increased in the Quan Fang group. The content of NE in the hippocampus of the Jiang Xia group and the Shen Cao group significantly increased. And the content of 5-HT also significantly increased in Quan Fang group, Chai Qin group, Shen Cao group. Moreover, the content of 5-HIAA in the hippocampus of the Quan Fang group, Chai Qin group and Jiang Xia group significantly increased. Conclusion: Minor Bupleurum Decoction has a good therapeutic effect on depression, each of the drugs on the role of brain tissue in rats with the target point of the neurotransmitter has a certain focus. Bupleurum and Scutellaria have antidepressant effects by increasing the content of 5-HT in rat hippocampus. Pinellia and ginger could significantly increase hippocampal NE content. Although the effects of the 5-HT were not significant, but it could significantly increase the content of 5-HT degradation of 5-HIAA; Ginseng, l Liquorice Root, and Chinese Date could significantly elevate the condition of depression 5-rat brain HT and NE content. |
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