| To investigate medicinal combination rules of removing-toxin Chinese patent medicine. Methods: Removing-toxin Chinese patent medicines were collected to build a database. Then associative rules combined with complex system clustering algorithms were applied to explore the co-relation between the frequency of medicinal use and associative rules. Results: The data-mining results indicated that in removing-toxin Chinese patent medicine, the most frequently used drugs were Glycyrrhizae Radix et Rhizoma, Borneolum Syntheticum, Lonicerae Japonicae Flos, Scutellariae Radix, Forsythia Fructus etc. The most frequently-used drug combinations were “Forsythia Fructus, Lonicerae Japonicae Flos”, “Forsythia Fructus, Scutellariae Radix” etc. The drug associative rules that the confidence was greater than 0.75 were “Moschus->Borneolum Syntheticum”, “Margarita->Borneolum Syntheticum”, “Bovis Calculus->Borneolum Syntheticum”. 40 core medicinal combinations and 20 new formulas were explored. Conclusion: From the analysis above, it is found that, in addition to medicinal with the function of clearing away heat and toxins, medicinals with the function of cooling blood, removing blood stasis, restoring consciousness and opening the orifice are commonly applied in removing-toxin formulas. |
