To explore the effects of Gubenfangxiao Decoction(GBFXD)on lung tissue ER stress-associated apoptotic gene CRT and EDEM in murine asthma remission models．Methods:According to former studies，OVA sensitization and RSV-OVA were used for stimulation and inducement on BALB/c female mice to build animal asthma remission models，which were then randomly grouped into normal group，model group，GBFXD high dose group，GBFXD medium dose group，GBFXD low dose group，Montelukast Sodium group and Dexamethasone group.The mRNA levels of ER stress-associated apoptotic genes CRT and EDEM were detected via RT-PCR method．Results:The lung tissue CRT expression of the model group is significantly higher than that of the normal group(P<0.05)； In GBFXD high dose group，GBFXD medium dose group，Montelukast Sodium group and Dexamethasone group，inhibited ER stress-associated apoptotic genes CRT were observed through the significant reduction of mRNA expressions after GBFXD treatment.(P<0.05)Conclusion:Guben Fangxiao Decoction significantly attenuates RSV-OVA-induced persistent airway inflammation in murine asthma remission model.These effects may be mediated，at least partially，by inhibiting the activation of ER stress-associated apoptotic genes CRT.