To evaluate six kinds of Chinese medicinal oral liquid on anti-inflammatory，analgesic and antipyretic effect on clinical treatment of catching cold.Methods:The anti-inflammatory effect was assessed by xylene-induced ear edema tests in mice.The analgesic effect was verified by HAc-induced writhing response in mice.The antipyretic action was monitored by dried yeast-induced pyrexia.Results:In all groups，Chinese medicinal oral liquid showed improved inflammatory response induced by HAc（P<0.05，P<0.01），while the efficacy of Pudilan group，Lanqin group，Danmu group and Shuanghuanglian group were slightly better than Chaigui group and Yinghuang group.All kinds of Chinese medicinal oral liquid ease the pain induced by HAc（P<0.05，P<0.01），while Lanqin group，Danmu group and Shuanghuanglian group were slightly better than Pudilan，Yinghuang group and Chaigui group.The fever induced by dried yeast was reduced by all kinds of Chinese material oral liquid，wihle Chaigui group，Shuanghuanglian group，Danmu group and Pudilan group were slightly better than Lanqin group and Yinghuang group.Conclusion:All six kinds of Chinese medicinal oral liquid had anti-inflammatory，analgesic and antipyretic efficacy，but slight differences on anti-inflammatory，analgesic and antipyretic effect between them existed.