To investigate the therapeutic effect of Huangkui Capsule for diabetic nephropathy at clinical stage and its impact on certain inflammatory factors, and to discuss its mechanism.Methods:A hundred and twenty patients who were admitted in the endocrinology department of our hospital from February 2012 to February 2014 and diagnosed as diabetic nephropathy at clinical stage were included as the research subjects and randomly divided into two groups with 60 cases in each. Patients in the control group received conventional western medicine treatment and five Huangkui capsules with three times a day were added for patients in the observation group compared with the control group. Patients in both groups were treated for 8 weeks. Changes of blood sugar, blood lipids, blood pressure, renal function and hs-CRP, TNF-α, IL-6, IL-8 and other inflammatory factors of patients in two groups were carefully monitored before and after treatment.Results:After treatment, the efficiency of the observation group was obviously superior to that of the control group, which showed statistically significant difference (P<0.05); blood sugar, blood lipids and blood pressure of the two groups were controlled with statistically significant differences (P<0.05 ); blood glucose of the observation group was better controlled than that of the control group, showing statistically significant difference (P<0.05); there was no statistically significant difference in control of blood pressure and blood lipids for the two groups (P>0.05). Urea nitrogen, 24 h urine protein and serum creatinine of the two groups were improved with statistically significant differences (P<0.05); those of the observation group were significantly better than those of the control group, showing statistically significant differences (P<0.05). Serum hs-CRP, TNF-α, IL-6, and IL-8 levels after treatment of both the two groups declined, which showed statistically significant differences (P<0.05); and the decrease in the observation group was significant than that of the control group, with statistically significant differences (P<0.05).Conclusion:Huangkui capsule may improve renal function for patients with diabetic nephropathy and reduce hs-CRP, TNF-α, IL-6, and IL-8 level with significant clinical effects, which is worthy of clinical application.