To explore the changes of LTB4、IL-8、TNF-α, and other inflammatory factors in patients with COPD in the stable phase after taking Shenha Yifei Capsule. Methods: Total 40 aged patients with COPD in our hospital from January 2012 to December 2014 were selected, the patients were randomly divided into study group and control group by random number table method. The control group were treated with clinical conventional treatment of COPD for stable phase of the aged patients, the study group were treated with Shenha Yifei Capsule on the basis of control group’s treatment. The changes of LTB4、IL-8、TNF-α after 3 months and 6 months were compared and analyzed, and the clinical therapeutic effect after six months’ treatment were compared. Results: The LTB4, TNF-8, IL-8 and other inflammatory factors of the control group after 3 and 6 months’ treatment declined, the study group had declined more with significant results (P<0.05);After six months’ treatment, there were 17 markedly effective cases, 20 effective cases, 3 invalid cases in the study group, the total effective rate was 92.5%, as for the control group, there were 10 cases markedly effective, 22 cases effective, 8 cases ineffective, the total effective rate was 80.0%, the division between the two groups was statistically significant (P<0.05). Conclusion: The treatment of Shenha Yifei Capsule combined with the conventional treatment can help decline the LTB4, IL-8, TNF-α and other inflammatory factors in aged patients with COPD, and improve the therapeutic effect.