| 引用本文:古远云，钟洪卫，陈辉，许志刚，欧雪梅.参蛤益肺胶囊对COPD稳定期老年患者LTB4、IL-8、TNF-α影响的研究[J].世界中医药,2016,(09):. |
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| 参蛤益肺胶囊对COPD稳定期老年患者LTB4、IL-8、TNF-α影响的研究 |
| Study on Effect of LTB4, TNF-and IL-8 in Aged Patients with Stable COPD |
| 投稿时间：2015-12-24 |
| DOI：10.3969/j.issn.1673-7202.2016.09.012 |
| 中文关键词: 参蛤益肺 COPD稳定期 白细胞三烯B4 白介素-8 肿瘤坏死因子-α |
| English Keywords:Shenha Yifei Capsule COPD stable phrase LTB4 IL-8 TNF-α |
| 基金项目:四川省中医药管理局资质基金项目(编号:cs66432)——“参蛤益肺胶囊对COPD稳定期老年患者LTB4、IL-8、TNF-α影响的研究” |
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| 中文摘要: |
| 目的:探讨对慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Diseases,COPD)稳定期老年患者应用参蛤益肺胶囊后的LTB4、IL-8、TNF-α等炎性反应因子的变化。方法:选取我院老年病科2012年1月至2014年12月收治的80例老年COPD患者,按照随机数字表法将80例患者随机分为研究组和对照组。对照组患者采用临床常规治疗COPD稳定期老年患者的治疗方案进行治疗,研究组患者在基础方案之上加用参蛤益肺胶囊进行治疗。比较分析治疗3、6个月后患者体内的LTB4、IL-8、TNF-α等炎性反应因子的变化以及治疗6个月后患者的临床治疗效果。结果:对照组患者在治疗后3、6个月后体内的LTB4、IL-8、TNF-α等炎性反应因子有一定程度下降,但研究组患者的上述指标下降程度更明显,组间数据比较,差异有统计学意义(P<0.05);在治疗6个月后对2组患者治疗效果进行评价发现,研究组患者显效17例、有效20例、无效3例,总有效率为92.5%,对照组患者显效10例、有效22例、无效8例,总有效率为80.0%,组间数据比较,差异有统计学意义(P<0.05)。结论:在常规治疗方案上加用参蛤益肺胶囊有助于COPD稳定期老年患者体内LTB4、IL-8、TNF-α等炎性反应因子的下降,并且能够提高治疗效果。 |
| English Summary: |
| To explore the changes of LTB4、IL-8、TNF-α, and other inflammatory factors in patients with COPD in the stable phase after taking Shenha Yifei Capsule. Methods: Total 40 aged patients with COPD in our hospital from January 2012 to December 2014 were selected, the patients were randomly divided into study group and control group by random number table method. The control group were treated with clinical conventional treatment of COPD for stable phase of the aged patients, the study group were treated with Shenha Yifei Capsule on the basis of control group’s treatment. The changes of LTB4、IL-8、TNF-α after 3 months and 6 months were compared and analyzed, and the clinical therapeutic effect after six months’ treatment were compared. Results: The LTB4, TNF-8, IL-8 and other inflammatory factors of the control group after 3 and 6 months’ treatment declined, the study group had declined more with significant results (P<0.05);After six months’ treatment, there were 17 markedly effective cases, 20 effective cases, 3 invalid cases in the study group, the total effective rate was 92.5%, as for the control group, there were 10 cases markedly effective, 22 cases effective, 8 cases ineffective, the total effective rate was 80.0%, the division between the two groups was statistically significant (P<0.05). Conclusion: The treatment of Shenha Yifei Capsule combined with the conventional treatment can help decline the LTB4, IL-8, TNF-α and other inflammatory factors in aged patients with COPD, and improve the therapeutic effect. |
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