To observe the clinical effect of Guizhi Gancao Longgu Muli Decoction therapy on patients with ventricular premature coronary heart disease.Methods:Sixty patients with coronary heart disease accompanied by ventricular premature beat due to treated in our hospital from May 2013 to March 2014 were selected and were randomly divided into the study group and the control group with 30 cases in each group. Patients in the control group were treated by the conventional coronary heart disease therapy, while Guizhi Gancao Longgu Muli decoction was added for patients in the study group accompanied with conventional coronary heart disease therapy. Patients in both the two groups received one-month treatment and the clinical effects of the two groups were compared after treatment.TCM clinical symptom scores were compared between the two groups before and after treatment. The total number of dynamic electrocardiogram of ventricular premature beat, S-T segment depression, T wave change number, and S-T segment pressure evaluation of clinical indicators of low amplitude before and after treatment were compared between the two groups.Results:The clinical efficiency after treatment in the study group was 96.7%, and that of the control group was 60.0%. There was significant difference between two groups (P<0.05). The clinical symptom scores of the two groups were improved after treatment, but the study group was significantly better than those of the control group, showing statistically significant difference (P<0.05). After treatment, two groups of the total number of dynamic electrocardiogram of ventricular premature beat and S-T segment depression, T wave change number, S-T segment depression range were improved, but in the study group, the total number of dynamic electrocardiogram of ventricular premature beat, S-T segment depression, T wave change number, and S-T segment depression clinical parameters of amplitude were significantly better than those of the control group with statistically significant difference (P<0.05).Conclusion:Guizhi Gancao Longgu Muli Decoction therapy in the treatment of coronary heart disease with premature ventricular contractions may significantly improve cardiac function in patients with exact clinical effect, which is worth of clinical promotion.