| 引用本文:傅志泉1，李珍2，曹红燕1，陈颖1，李清林3.大承气汤对急性胃肠损伤患者免疫功能影响的临床评价[J].世界中医药,2016,(09):. |
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| 大承气汤对急性胃肠损伤患者免疫功能影响的临床评价 |
| Curative Effect Evaluation of Da-cheng-qi Decoction on Immunal Function in Patients with Acute Gastrointestinal Injury |
| 投稿时间：2015-11-04 |
| DOI：10.3969/j.issn.1673-7202.2016.09.015 |
| 中文关键词: 急性胃肠损伤 中医药疗法 大承气汤 |
| English Keywords:Acute gastrointestinal injury TCM therapy Da-cheng-qi Decoction |
| 基金项目:上海市自然科学基金项目（编号：16ZR1433800）——基于肠道菌群结构特征研究大承气汤改善胃肠功能障碍患者肠道屏障功能的作用机制 |
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| 中文摘要: |
| 目的：研究通腑中药大承气汤对AGI患者的治疗作用及对机体免疫功能的影响。方法：将69例AGI患者随机分为2组，对照组40例，单纯采用一般对症、补液支持治疗；观察组29例，在对照组治疗的基础上加用口服/灌肠大承气汤汤剂，分别比较治疗前后T淋巴细胞亚群、NK活性、WBC及CRP、PCT、IL-6的改变，并进行APACHEⅡ评分。结果：治疗2周后2组胃肠功能均较前改善，观察组恢复更为迅速(P<0.01)；2组经治疗后APACHEⅡ评分较治疗前均有下降（P<0.05），与对照组比较，治疗组评分下降更显著（P<0.01），治疗2周后，观察组NK、CD3+、CD4+细胞计数明显升高，CD8+细胞计数减少，CD4+／CD8+比值明显升高，差异有统计学意义；治疗后观察组WBC、CRP、PCT、IL-6表达水平较治疗前明显降低，差异有统计学意义。对照组经治疗后CD3+、CD4+细胞数表达下降，而CD8+细胞数相对增加，CD4+／CD8+比值降低；WBC总数、CRP、PCT、IL-6较与治疗前相比，无显著差异。结论：以大承气汤为代表的“通腑法”对AGI患者有较好的通腑逐邪作用，并能通过逐邪来固护正气，恢复机体的免疫功能，提高临床疗效。 |
| English Summary: |
| To research the clinical effect of Da-cheng-qi Decoction in improving the gastrointestinal function and immune function in patients with Acute Gastrointestinal Injury (AGI).Methods:Sixty-nine patients were randomly divided into control group and treatment group. Forty patients in the control group received only conventional therapy and 29 patients in the treatment group were treated with Da-cheng-qi Decoction via oral-taking or enema combined with conventional therapy.Results:After 2-week treatment, the recovery of gastrointestinal function was significantly different between the two groups, while that of the observation group was more rapidly (P<0.01). Compared with the control group, the APACHE Ⅱ score of the treatment group significantly decreased (P<0.01). The percentages of CD3+, CD4+, CD4+/CD8+ and NK cells in the treatment group increased and the CD8+ cells reduced more obviously than that of the control group, which showed statistically significant difference (P<0.01). the counts of leukocytes, procalcitonin and IL-6 were significantly improved in the traditional Chinese medicine group, compared with that of the control group (P<0.01).Conclusion:Purgative method represented by Da-cheng-qi Decoction may promote the recovery of gastrointestinal function and immune function, which has good clinical effect on patients with AGI. |
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