To investigate the clinical efficacy in the treatment of qi deficiency and blood stasis syndrome ischemic stroke patients with Qi-Tonifying and Stasis-Removing Decoction and sanqi panax notoginseng for injection，and explore the influence of neurologic improvement，MMP-9，SOD and MDA levels.Methods:A total of 116 patients were randomly divided into control group with 58 cases and observation group with 58 cases.Patients in the control group were treated with edaravone injection for intravenous drip，while patients in the observation group were treated with Qi-Tonifying and Stasis-Removing Decoction and sanqi panax notoginseng for injection，the treatment lasted for 4 weeks.The clinical effect，the patients’ degree of nerve function defect，the change of hemorheology，MMP-9，SOD and MDA levels were detected.Results:The effective rate of patients in the observation group was 91.3%，which was higher than that of the control group 75.9%(P<0.05)； The improvement of nerve function for the patients in the observation group was better than that of the control group after treatment，and the NIHSS scores were lower than that of the control group(P<0.05)； The improvement of cerebral microcirculation for the patients in the observation group was better than that of the control group after treatment，and the blood rheology indicators were lower than that of the control group(P<0.05)； The MMP-9 and MDA levels of the observation group were lower than the control group after treatment，while the SOD activity was higher than that of the control group(P<0.05).Conclusion:The therapy has good effect，for its improvement in patients’ nerve function and cerebral microcirculation.The mechanism may be associated with regulating the levels of MMP-9，SOD and MDA.