To investigate the effect of Bowels Relaxing and Orifice Opening Decoction on patients with acute cerebral infarction with coma in order to improve the clinical outcome.Methods:Total 46 cases of acute cerebral infarction coma patients during May 2009 to May 2014 in this study were divided into two groups，the control group with 23 patients were given conventional western medicine treatment，the 23 cases in the observation group received Bowels Relaxing and Orifice Opening Decoction with western medicine.The sober duration and related indicators changes were observed before and after the treatment.Results:The total curative rate of control group was 21.74%，the total effective rate was 82.61%，while the total curative rate of observation group was 43.48%，the total effective rate was 95.65%，the differences were significant(P<0.05)； in the control group the average sober duration was(6.23±1.13)d，the observation group(4.11±0.88)d，significantly shorter than the control group(P<0.05)； after treatment，the GCS score，ADL score，t-PA of the two group significantly improved，and NIHSS score and PAI decreased significantly(P<0.05).After treatment，the GCS score，ADL score，t-PA of the observation group increased more significantly，NIHSS score，PAI decline decreased more significantly(P<0.05).Conclusion:Bowels Relaxing and Orifice Opening Decoction can shorten the duration of coma with acute cerebral infarction with better efficacy.