| 引用本文:邱智辉1，黄毅斌2，陈春雷3，邓乐1，刘凡1，张美平1，范建喜1.自拟丹皮汤治疗病毒性肝炎肝硬化的临床研究[J].世界中医药,2016,(09):. |
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| 自拟丹皮汤治疗病毒性肝炎肝硬化的临床研究 |
| Clinical Study of Danpi Decoction in the Treatment of Viral Hepatitis with Cirrhosis |
| 投稿时间：2015-12-14 |
| DOI：10.3969/j.issn.1673-7202.2016.09.023 |
| 中文关键词: 病毒性肝炎 肝硬化 丹皮汤 |
| English Keywords:Viral hepatitis Liver cirrhosis Danpi (Moutan Cortex) Decoction |
| 基金项目:深圳市2015年度科技创新计划基础研究项目（编号：2015-170） |
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| 中文摘要: |
| 目的：探讨自拟丹皮汤治疗病毒性肝炎肝硬化的临床疗效。方法：运用随机数字表法将106例病毒性肝炎肝硬化患者分为2组（每组53例），对照组患者应用抗病毒西药进行治疗，研究组在对照组基础上加用自拟丹皮汤，比较2组患者用药前后的中医证候积分、肝功能指标变化。结果：研究组治疗后的ALT、AST、TBIL、ALB水平均明显低于对照组，P<0.05。研究组治疗后的MPV、SPV、脾长度、脾厚度值均较治疗前明显降低，并且与对照组比较均有统计学意义（P<0.05）。研究组治疗后的中医证候评分、CLDQ评分明显低于对照组，P<0.05。研究组的治疗总有效率为98.11%，显著高于对照组的83.02%（P<0.05）。治疗后，2组的TGF-β1水平均明显降低，且研究组治疗后的TGF-β1水平显著低于对照组（P<0.05）。结论：自拟丹皮汤辅助治疗病毒性肝炎肝硬化，能有效改善患者的临床症状及体征，改善肝功能，对抗肝纤维化过程。 |
| English Summary: |
| To discuss the curative effect of Danpi (Moutan Cortex) Decoction in the treatment of cirrhosis due to viral hepatitis. Methods: A hundred and six cases of patients with cirrhosis due to viral hepatitis were ramdomly divided into two groups by random number table (53 cases of each group). Patients in the both control and study group were treated with Western medicine for antiviral treatment and those in the study group was additionally treated with Danpi Decoction. Changes of TCM syndrome integral, liver function index of patients in the both groups before and after the treatment were compared. Results: ALT, TBIL, AST, and ALB levels of the study group after treatment were significantly lower than those of the control group (P<0.05). MPV, SPV, spleen length and spleen thickness of the study group were significantly decreased than those before the treatment and those of the control group with significant differences (P<0.05). The TCM syndrome score and CLDQ score of the study group after treatment were significantly lower than those of the control group (P<0.05). After the treatment, the TGF-β1 levels of both the groups were significantly decreased, and the level in the study group was significantly lower than that in the control group (P<0.05). Conclusion: Danpi Decoction may help the treatment of liver cirrhosis due to viral hepatitis and it may effectively improve the clinical symptoms and signs, enhance liver function and prevent liver fibrosis. |
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