To discuss the curative effect of Danpi (Moutan Cortex) Decoction in the treatment of cirrhosis due to viral hepatitis. Methods: A hundred and six cases of patients with cirrhosis due to viral hepatitis were ramdomly divided into two groups by random number table (53 cases of each group). Patients in the both control and study group were treated with Western medicine for antiviral treatment and those in the study group was additionally treated with Danpi Decoction. Changes of TCM syndrome integral, liver function index of patients in the both groups before and after the treatment were compared. Results: ALT, TBIL, AST, and ALB levels of the study group after treatment were significantly lower than those of the control group (P<0.05). MPV, SPV, spleen length and spleen thickness of the study group were significantly decreased than those before the treatment and those of the control group with significant differences (P<0.05). The TCM syndrome score and CLDQ score of the study group after treatment were significantly lower than those of the control group (P<0.05). After the treatment, the TGF-β1 levels of both the groups were significantly decreased, and the level in the study group was significantly lower than that in the control group (P<0.05). Conclusion: Danpi Decoction may help the treatment of liver cirrhosis due to viral hepatitis and it may effectively improve the clinical symptoms and signs, enhance liver function and prevent liver fibrosis.