To analyze the effect and mechanism of Shenxiong glucose injection in treating coronary heart disease (CHD).Methods:A total of 104 patients with CHD were divided into control group and treatment group according to random number table with 52 cases in each group.The control group was treated by conventional western medicine,such as stable plaques,anti platelet aggregation,and so on.The treatment group was treated by Shenxiong glucose injection 100 mL on the basis of medication of the control group,twice a day.Results:The effective rate was 63.46% in control group and 86.53% in treatment group,and the difference was statistically significant (P<0.05).The lipid metabolism and IMA of treatment group were obviously improved compared with before treatment.Also,compared the improvements of the control group,the difference was statistically significant (P<0.05).Conclusion:Shenxiong Glucose injection in the treatment of CHD has distinct clinical curative effect.Its treatment mechanism is mainly manifested by its effect on lipid metabolism,improving the coronary blood supply and reducing blood viscosity.