To evaluate the clinical efficacy of Tiaowei Xinpi decoction in improving the symptoms of advanced cancer cachexia.Methods:A randomized controlled clinical trial was conducted.Sixty-three patients meet the entry criteria were randomly divided into treatment group (32 cases) and control group (31 cases).The treatment group received Tiaowei Xinpi decoction and the control group received megestrol acetate tablet.Each group takes one week as a treatment session and was treated for 2 sessions.Observe the TCM symptom score in the day before treatment,the first day and fifteenth day after treatment.Results:After 1 day and 15 day of treatment,the difference between the two groups in TCM symptom score in weight loss,shortness of breath,and weakness before and after treatment have no statistically significant difference (P>0.05),which indicated that both the drugs in the treatment group and the control group have a positive effect on improving these symptoms.However,there are significant difference in the improvement of anorexia and abdominal distension (P<0.05),and the TCM symptom score in treatment group decreased more significantly than that of the control group,indicating that the treatment group drug can achieve more obvious effect in improving anorexia and abdominal distention.Conclusion:In the improvement of TCM syndrome,and as regard to either short-term efficacy or long-term efficacy,Tiaowei Xinpi decoction was better than megestrol acetate.Also,both in the short-term efficacy or long-term efficacy,Tiaowei Xinpi Decoction achieve more obvious effect in improving TCM symptoms of anorexia,abdominal distension than megestrol acetate.