To observe the clinical curative effect of Shengxian Jieyu Pill combined with Tongue three needle treatment of aphasia after stroke. Methods: Total 102 patients with aphasia after stroke were included, according to random number table method and were divided into two groups, with 51 cases in each group. Both two groups adopted ShuErShi line (Schuell) stimulus speech rehabilitation training, 30 min/time, 3 times per week. control group were treated with tongue three needle treatment, and the observation group were treated with Shengxian Jieyu Pill on the basis of the above treatment. Treatment of both groups lasted for 4 weeks. Chinese rehabilitation research center aphasia examination (CRRCAE) table was used to evaluate the speech function; the degree of nerve function defect score scale (CSS) to evaluate nerve damage function deficiency, the evaluation was performed both once before and after the treatment. Results: The aphasia clinical total effective rate of the observation group was 96.08%, higher than control group’s 82.35% (χ2=4.993, P<0.05）; The CRRCAE improved in both groups after treatment significantly (P<0.01）; factor’s scores on CRRCAE checklist of the observation group were significantly higher than control group (P<0.0）; CSS scores of the two groups were significantly lower after treatment (P<0.0）, and CSS score of the observation group was lower than the control group (P<0.0）. Conclusion: Shengxian Jieyu Pill combined with tongue three needle treatment has good clinical effect on patients with aphasia after stroke, which worthy of clinical use.