| 引用本文:李君玲.炎琥宁注射液、小儿清热宣肺贴膏联合氨溴特罗口服溶液治疗小儿急性支气管炎的临床研究[J].世界中医药,2016,(09):. |
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| 炎琥宁注射液、小儿清热宣肺贴膏联合氨溴特罗口服溶液治疗小儿急性支气管炎的临床研究 |
| Clinical Research on Acute Bronchitis of Children Treated with Potassium Sodium Dehydroandrographolide Succinate Injection, Removing Hot & Ventilating Lung Paste Combining with Ambrocol Oral Solution |
| 投稿时间：2015-10-27 |
| DOI：10.3969/j.issn.1673-7202.2016.09.029 |
| 中文关键词: 急性支气管炎 炎琥宁注射液 小儿 清热宣肺贴膏 氨溴特罗口服溶液 |
| English Keywords:Acute bronchitis Potassium sodium dehydroandroandrographolide succinate injection Children Removing hot & ventilating lung paste Ambrocol oral solution |
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| 中文摘要: |
| 目的：观察用炎琥宁注射液、小儿清热宣肺贴膏联合氨溴特罗口服溶液治疗小儿急性支气管炎的临床效果。方法：选取136例急性支气管炎患儿按照随机数字表法分为对照组和治疗组各68例，2组患儿均给予常规对症支持治疗，对照组加用氨溴特罗口服溶液，治疗组患者在此基础上给予炎琥宁注射液、小儿清热宣肺贴膏联合治疗，2组均连续治疗1周。治疗前后评价其中医证候积分，记录主要症状的消失时间，检测肺功能变化及炎性因子水平变化，评估其有效性和安全性。结果：观察组的有效率91.2%明显高于对照组有效率75%，症状改善时间较对照组明显缩短，差异有统计学意义（P<0.05）；治疗后观察组患者证候积分显著低于对照组患者，肺功能指标FEV1、FVC、PEF%较对照组显著提高，炎性因子hs-CRP、TNF-α、IL-4、IgE水平明显低于对照组,有统计学意义（P<0.05）。结论：本研究治疗小儿急性支气管炎能显著改善患者症状，有效缩短病程，提高肺功能，疗效确切，其机制与调控炎性递质水平密切相关。 |
| English Summary: |
| To observe the clinical efficacy of potassium sodium dehydroandroandrographolide succinate injection, removing hot & ventilating lung paste combining with ambrocol oral solution on acute bronchitis of children. Methods: A total of 136 cases were randomly divided into the control group and the treatment group, with 68 cases in each group. Patients in two groups were treated with general symotomatic and supportive treatment. Besides, ambrocol oral solution was applied in the control group, while the treatment group was given the combination of potassium sodium dehydroandroandrographolide succinate injection and removing hot & ventilating lung paste. Each group was treated continuously for 1 week. The research was aimed at observing the improvement of the main clinical symptoms and evaluating its TCM syndrome integral. The disappearing time of main symptoms was recorded. Monitor the changes of lung function and inflammatory factors. Evaluate the effectiveness and safety. Results: The effective rate in the treatment group was obviously higher than that in the control group, with 91.2%, 75% respectively. Compare with the control group, the time needed for improvement of symptoms was significantly less in the treatment group. The difference between the two groups was significant (P<0.05). The symptom scores in the treatment group were lower than that in the control group. The levels of lung function indices FEV1, FVC and PEF% were higher than those in the control group while levels of inflammatory factors as hs-CRP, TNF-α, IL-4 and IgE were lower in the treatment group than those in the control group. The difference between the two groups was significant (P<0.05). Conclusion: The treatment can effectively improve symptoms, shorten courses of the disease and enhance lung function, which shows exact effects. The mechanism of the treatment can be related with the regulation of inflammatory mediator. |
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