To observe the clinical efficacy of potassium sodium dehydroandroandrographolide succinate injection, removing hot & ventilating lung paste combining with ambrocol oral solution on acute bronchitis of children. Methods: A total of 136 cases were randomly divided into the control group and the treatment group, with 68 cases in each group. Patients in two groups were treated with general symotomatic and supportive treatment. Besides, ambrocol oral solution was applied in the control group, while the treatment group was given the combination of potassium sodium dehydroandroandrographolide succinate injection and removing hot & ventilating lung paste. Each group was treated continuously for 1 week. The research was aimed at observing the improvement of the main clinical symptoms and evaluating its TCM syndrome integral. The disappearing time of main symptoms was recorded. Monitor the changes of lung function and inflammatory factors. Evaluate the effectiveness and safety. Results: The effective rate in the treatment group was obviously higher than that in the control group, with 91.2%, 75% respectively. Compare with the control group, the time needed for improvement of symptoms was significantly less in the treatment group. The difference between the two groups was significant (P<0.05). The symptom scores in the treatment group were lower than that in the control group. The levels of lung function indices FEV1, FVC and PEF% were higher than those in the control group while levels of inflammatory factors as hs-CRP, TNF-α, IL-4 and IgE were lower in the treatment group than those in the control group. The difference between the two groups was significant (P<0.05). Conclusion: The treatment can effectively improve symptoms, shorten courses of the disease and enhance lung function, which shows exact effects. The mechanism of the treatment can be related with the regulation of inflammatory mediator.