To observe the effect of Tonifying Spleen and Blood Generating Granule on mild to moderate active systemic lupus erythematosus with anemia.Methods:A total of 47 patients with systemic lupus erythematosus with anemia were randomly divided into control and treatment groups.The control group received glucocorticoids(prednisone / methylprednisolone)，the treatment group received glucocorticoids(prednisone / methylprednisolone)and Tonifying Spleen and Blood Generating Granule.The effective rate of anemia and the changes of hemoglobin(Hb)，hematocrit(HCT)，serum ferritin(SF)，SLE activity and ESR，IgA，IgG，C3，and the amount of hormone usage of the two groups were observed after 2 months.Results:The effective rate between the treatment group and the control group showed no significant difference(P>0.05).There were significant differences(P<0.05)in two groups’ Hb，HCT，SF and SLEDAI score(P<0.05)； one month after treatment，the Hb，HCT，SF of the two groups were significantly different(P<0.05)，but SLEDAI scores of showed no significant difference(P>0.05)； Hb，HCT，SF and SLEDAI score(P<0.05)showed no differences after the treatment.The ESR，IgA，IgG，C3 of the two groups were significantly different(P<0.05)but after 1 month of treatment，it showed no significantly differences(P>0.05)as well as total hormone dosage(P>0.05).After 2 months of treatment，the total amount of hormone dosage of the two groups was statistically significant(P<0.05).Conclusion:Tonifying Spleen and Blood Generating Granule can improve mild to moderate anemia in systemic lupus erythematosus with faster effect than using hormones alone，which is worthy of clinical application.