| 引用本文:范高俊1，潘静2，刘益源1，裴学军3，肖飞3.健脾生血颗粒治疗轻中度活动期系统性红斑狼疮合并贫血的临床观察[J].世界中医药,2016,(09):. |
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| 健脾生血颗粒治疗轻中度活动期系统性红斑狼疮合并贫血的临床观察 |
| Clinical Observation of Tonifying Spleen and Blood Generating Granule in Treatment of Systemic Lupus Erythematosus with Anemia in Mild to Moderate Active Stage |
| 投稿时间：2016-06-30 |
| DOI：10.3969/j.issn.1673-7202.2016.09.034 |
| 中文关键词: 健脾生血颗粒 轻中度活动期 系统性红斑狼疮 贫血 |
| English Keywords:Tonifying Spleen and Blood Generating Granule Mild to moderate active stage Systemic lupus erythematosus Anemia |
| 基金项目:武汉市科技攻关计划（编号：２０１３０７０２０４０２００５３） |
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| 中文摘要: |
| 目的：观察健脾生血颗粒对轻中度活动期系统性红斑狼疮合并贫血的影响。方法：将47例符合系统性红斑狼疮合并贫血的患者随机分为对照组和治疗组。对照组给予糖皮质激素（泼尼松/甲泼尼龙），治疗组给予糖皮质激素（泼尼松/甲泼尼龙）+健脾生血颗粒，持续观察2个月。观察治疗贫血的有效率及治疗前后血红蛋白（Hb）、血细胞比容（HCT）、血清铁蛋白（SF）、SLE活动性及ESR、IgA、IgG、C3的变化以及激素使用量。结果：治疗组总有效率与对照组无统计学意义（P>0.05）。2组Hb、HCT、SF及SLEDAI积分治疗后较治疗前均有显著改善（P<0.05）；治疗1个月后治疗组Hb、HCT、SF较对照组有统计学意义（P<0.05），SLEDAI积分较对照组无统计学意义（P>0.05）；治疗后治疗组Hb、HCT、SF及SLEDAI积分较对照组无统计学意义（P>0.05）。2组ESR、IgA、IgG、C3治疗前后有统计学意义（P<0.05）；治疗1个月和治疗后，2组ESR、IgA、IgG、C3均无统计学意义（P>0.05）。治疗1个月后，2组激素使用总量无统计学意义（P>0.05）。治疗2个月后，2组激素使用总量有统计学意义（P<0.05）。结论：健脾生血颗粒具有改善轻中度活动期系统性红斑狼疮合并贫血的作用，且较单独使用激素，起效更快，值得临床推广应用。 |
| English Summary: |
| To observe the effect of Tonifying Spleen and Blood Generating Granule on mild to moderate active systemic lupus erythematosus with anemia.Methods:A total of 47 patients with systemic lupus erythematosus with anemia were randomly divided into control and treatment groups.The control group received glucocorticoids(prednisone / methylprednisolone)，the treatment group received glucocorticoids(prednisone / methylprednisolone)and Tonifying Spleen and Blood Generating Granule.The effective rate of anemia and the changes of hemoglobin(Hb)，hematocrit(HCT)，serum ferritin(SF)，SLE activity and ESR，IgA，IgG，C3，and the amount of hormone usage of the two groups were observed after 2 months.Results:The effective rate between the treatment group and the control group showed no significant difference(P>0.05).There were significant differences(P<0.05)in two groups’ Hb，HCT，SF and SLEDAI score(P<0.05)； one month after treatment，the Hb，HCT，SF of the two groups were significantly different(P<0.05)，but SLEDAI scores of showed no significant difference(P>0.05)； Hb，HCT，SF and SLEDAI score(P<0.05)showed no differences after the treatment.The ESR，IgA，IgG，C3 of the two groups were significantly different(P<0.05)but after 1 month of treatment，it showed no significantly differences(P>0.05)as well as total hormone dosage(P>0.05).After 2 months of treatment，the total amount of hormone dosage of the two groups was statistically significant(P<0.05).Conclusion:Tonifying Spleen and Blood Generating Granule can improve mild to moderate anemia in systemic lupus erythematosus with faster effect than using hormones alone，which is worthy of clinical application. |
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